WO2025224298 - INHIBITORS OF MALT1 AND METHODS OF THEIR USE

National phase entry is expected:
Publication Number WO/2025/224298
Publication Date 30.10.2025
International Application No. PCT/EP2025/061322
International Filing Date 25.04.2025
Title **
[English] INHIBITORS OF MALT1 AND METHODS OF THEIR USE
[French] INHIBITEURS DE MALT1 ET MÉTHODES POUR LEUR UTILISATION
Applicants **
JANSSEN PHARMACEUTICA NV
JOHNSON & JOHNSON (CHINA) INVESTMENT LTD.
Inventors
FONTAN GABAS, Lorena
HODKINSON, Brendan Paul
PHILIPPAR, Ulrike
SRINIVASAN, Srimathi Santhanam
MOWAT, Jeffrey Stuart
THURING, Johannes Wilhelmus J.
HULPIA, Fabian
LEPRI, Susan
PESCHIULLI, Aldo
VAN ROOSBROECK, Yves Emiel Maria
VELTER, Adriana-Ingrid
MUURONEN, Mikko Juhani Artturi
WROBLOWSKI, Berthold
Priority Data
PCT/CN2024/090170   26.04.2024   CN
PCT/CN2024/090178   26.04.2024   CN
PCT/CN2024/099801   18.06.2024   CN
PCT/CN2024/099802   18.06.2024   CN
63/662,020   20.06.2024   US
PCT/CN2024/101273   25.06.2024   CN
63/666,733   02.07.2024   US
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译文

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Quotation for National Phase entry

Country StagesTotal
China Filing, Examination, Granting2843
EPO Filing, Examination, Granting11972
Japan Filing, Examination, Granting2307
South Korea Filing, Examination, Granting2576
USA Filing, Examination, Granting4740
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Total: 24,438
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Abstract[English] Methods for treating a B-cell malignancy in a human subject are described. The methods involve determining the presence or absence of a B-cell activating mutation in a gene(s) obtained from the subject. Methods include treatment with the compound of formula (I).[French] L'invention concerne des méthodes de traitement d'une malignité des lymphocytes B chez un sujet humain. Les méthodes consistent à déterminer la présence ou l'absence d'une mutation d'activation de lymphocytes B dans un ou plusieurs gènes obtenus à partir du sujet. Les méthodes comprennent le traitement avec le composé de formule (I).