WO2025093398 - DNA UNFOLDING USING A FREE-END TAG FLOW MODIFIER
National phase entry is expected:
Publication Number
WO/2025/093398
Publication Date
08.05.2025
International Application No.
PCT/EP2024/079961
International Filing Date
23.10.2024
Title **
[English]
DNA UNFOLDING USING A FREE-END TAG FLOW MODIFIER
[French]
DÉPLIAGE D'ADN À L'AIDE D'UN MODIFICATEUR DE FLUX D'ÉTIQUETTE À EXTRÉMITÉ LIBRE
Applicants **
ROBERT BOSCH GMBH
Inventors
JOHNSON, Christopher
GRUMAZ, Christian
PILSL, Sebastian
FOMINA, Nadezda
GADELRAB, Karim
Priority Data
18/499328
01.11.2023
US
Application details
| Total Number of Claims/PCT | * |
| Number of Independent Claims | * |
| Number of Priorities | * |
| Number of Multi-Dependent Claims | * |
| Number of Drawings | * |
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| Pages of Specification | * |
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| Number of Office Actions | * |
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International Searching Authority |
EPO
* |
| Recordal of a Change of the Applicant's Name/Address |
Change of Applicant's Name and Address
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| Type of Assignment |
The Standard Agent's Assignment
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| Applicant's Legal Status |
Legal Entity
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| * | |
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| Entry into National Phase under |
Chapter I
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| Patent Delivery |
Send the Letters Patent by Courier
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| 译文 |
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** IP-Coster compiles data from publicly available sources. If this data includes your personal information, you can contact us to request its removal.
Quotation for National Phase entry
| Country | Stages | Total | |
|---|---|---|---|
| China | Filing, Examination, Granting | 2185 | |
| EPO | Filing, Examination, Granting | 11358 | |
| Japan | Filing, Examination, Granting | 2372 | |
| South Korea | Filing, Examination, Granting | 2549 | |
| USA | Filing, Examination, Granting | 4740 |
Total:
23,204
The term for entry into the National Phase has expired. This quotation is for informational purposes only
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Abstract[English]
Methods for leveraging the charged nature of DNA to promote DNA extension and manipulate its orientation are provided. The methods include attaching highly charged molecules to a free end of a DNA molecule to transform the DNA molecule into a pseudo dipole. Upon applying an external electric field, the charge separation may cause the DNA to extend and/or to align with the electric field lines. This approach offers a practical means to achieve a controlled, unfolded state of DNA with a predetermined orientation.[French]
L'invention concerne des procédés pour exploiter la nature chargée d'ADN pour favoriser l'extension de l'ADN et manipuler son orientation. Les procédés comprennent la fixation de molécules hautement chargées à une extrémité libre d'une molécule d'ADN pour transformer la molécule d'ADN en un pseudo-dipôle. Lors de l'application d'un champ électrique externe, la séparation de charge peut amener l'ADN à s'étendre et/ou à s'aligner avec les lignes de champ électrique. Cette approche offre un moyen pratique pour obtenir un état d'ADN déplié régulé avec une orientation prédéterminée.