WO2024033280 - FUROPYRIDIN AND FUROPYRIMIDIN, INHIBITORS OF PI4K, FOR USE IN THE TREATMENT OF PARASITE INFECTION AND MALARIA

National phase entry is expected:
Publication Number WO/2024/033280
Publication Date 15.02.2024
International Application No. PCT/EP2023/071761
International Filing Date 07.08.2023
Title **
[English] FUROPYRIDIN AND FUROPYRIMIDIN, INHIBITORS OF PI4K, FOR USE IN THE TREATMENT OF PARASITE INFECTION AND MALARIA
[French] FUROPYRIDINE ET FUROPYRIMIDINE, INHIBITEURS DE PI4K, DESTINÉS À ÊTRE UTILISÉS DANS LE TRAITEMENT D'UNE INFECTION PARASITAIRE ET DU PALUDISME
Applicants **
MERCK PATENT GMBH
Inventors
KULKARNI, Shashank
SPANGENBERG, Thomas
CABRERA, Diego Gonzales
KANDEPEDU, Nishanth
VON GELDERN, Thomas W.
BASARAB, Gregory
Priority Data
63/370,838   09.08.2022   US
63/480,808   20.01.2023   US
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Quotation for National Phase entry

Country StagesTotal
China Filing, Examination, Granting4244
EPO Filing, Examination, Granting19793
Japan Filing, Examination, Granting2401
South Korea Filing, Examination, Granting2608
USA Filing, Examination, Granting9540
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Total: 38,586

The term for entry into the National Phase has expired. This quotation is for informational purposes only

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Abstract[English] The present invention relates to novel compounds having valuable properties, in particular those which can be used for the preparation of medicaments as well as methods of their use and manufacture. Said compounds are particularly useful as PI4K inhibitors and for the treatment or prevention of PI4K-related disorders such as protozoan infections like malaria and virus infections.[French] La présente invention concerne de nouveaux composés ayant des propriétés d'intérêt, en particulier ceux qui peuvent être utilisés pour la préparation de médicaments, ainsi que des procédés d'utilisation et de fabrication de ceux-ci. Lesdits composés sont particulièrement utiles en tant qu'inhibiteurs de PI4K et pour le traitement ou la prévention de troubles liés à PI4K tels que des infections protozoaires, notamment la malaria et des infections virales.