WO2026139021 - ANTI-PD-L1 AND 4-1BB BISPECIFIC ANTIBODY AND USE THEREOF
National phase entry is expected:
Publication Number
WO/2026/139021
Publication Date
02.07.2026
International Application No.
PCT/CN2025/145934
International Filing Date
26.12.2025
Title **
[English]
ANTI-PD-L1 AND 4-1BB BISPECIFIC ANTIBODY AND USE THEREOF
[French]
ANTICORPS BISPÉCIFIQUE ANTI-PD-L1 ET 4-1BB ET SON UTILISATION
[Chinese]
抗PD-L1和4-1BB双特异性抗体及其应用
Applicants **
BIO-THERA SOLUTIONS, LTD.
Inventors
LIU, Guosheng
CHEN, Caiyan
HUANG, Xianming
Priority Data
202411945766.7
27.12.2024
CN
Application details
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International Searching Authority |
CNIPA
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| Recordal of a Change of the Applicant's Name/Address |
Change of Applicant's Name and Address
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| Type of Assignment |
The Standard Agent's Assignment
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| Applicant's Legal Status |
Legal Entity
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| Entry into National Phase under |
Chapter I
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| Patent Delivery |
Send the Letters Patent by Courier
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| 译文 |
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* The data is based on automatic recognition. Please verify and amend if necessary.
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Quotation for National Phase entry
| Country | Stages | Total | |
|---|---|---|---|
| China | Filing, Examination, Granting | 3139 | |
| EPO | Filing, Examination, Granting | 40844 | |
| Japan | Filing, Examination, Granting | 3578 | |
| South Korea | Filing, Examination, Granting | 5206 | |
| USA | Filing, Examination, Granting | 18340 |
Total:
71,107
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Abstract[English]
The present invention belongs to the field of biomedicine. Provided are a bispecific antibody and the use thereof. The bispecific antibody contains a first antigen-binding domain targeting PD-L1 and a second antigen-binding domain targeting 4-1BB. The antibody retains the activity of an anti-PD-L1 antibody, achieves a balance between activity and safety, and has an excellent druggability potential.[French]
La présente invention se rapporte au domaine de la biomédecine. L'invention concerne un anticorps bispécifique et son utilisation. L'anticorps bispécifique contient un premier domaine de liaison à l'antigène ciblant PD-L1 et un second domaine de liaison à l'antigène ciblant 4-1BB. L'anticorps conserve l'activité d'un anticorps anti-PD-L1, atteint un équilibre entre l'activité et la sécurité, et a un excellent potentiel de pharmacopotentialité.[Chinese]
属于生物医药领域，提供双特异性抗体及其应用，所述双特异性抗体包含靶向PD-L1的第一抗原结合域和靶向4-1BB的第二抗原结合域。抗体保留了抗PD-L1抗体的活性，实现活性和安全性的平衡，具有非常优良的成药潜力。