WO2026130567 - TRISUBSTITUTED TETRAHYDROISOQUINOLINE AMIDE DERIVATIVE AND PHARMACEUTICAL USE THEREOF
National phase entry is expected:
Publication Number
WO/2026/130567
Publication Date
25.06.2026
International Application No.
PCT/CN2025/144156
International Filing Date
21.12.2025
Title **
[English]
TRISUBSTITUTED TETRAHYDROISOQUINOLINE AMIDE DERIVATIVE AND PHARMACEUTICAL USE THEREOF
[French]
DÉRIVÉ D'AMIDE DE TÉTRAHYDROISOQUINOLÉINE TRISUBSTITUÉE ET UTILISATION PHARMACEUTIQUE DE CELUI-CI
[Chinese]
一种三取代四氢异喹啉酰胺类衍生物及其医药应用
Applicants **
HANGZHOU SHOUYAN BIOPHARMACEUTICAL TECHNOLOGY CO., LTD.
Inventors
WANG, Yi
GAO, Yinhua
Priority Data
202411895398.X
21.12.2024
CN
Application details
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International Searching Authority |
CNIPA
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| Recordal of a Change of the Applicant's Name/Address |
Change of Applicant's Name and Address
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| Type of Assignment |
The Standard Agent's Assignment
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| Applicant's Legal Status |
Legal Entity
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| Entry into National Phase under |
Chapter I
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| Patent Delivery |
Send the Letters Patent by Courier
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| 译文 |
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Quotation for National Phase entry
| Country | Stages | Total | |
|---|---|---|---|
| China | Filing, Examination, Granting | 1931 | |
| EPO | Filing, Examination, Granting | 12330 | |
| Japan | Filing, Examination, Granting | 2215 | |
| South Korea | Filing, Examination, Granting | 2200 | |
| USA | Filing, Examination, Granting | 4740 |
Total:
23,416
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Abstract[English]
Provided is a trisubstituted tetrahydroisoquinoline amide derivative or a pharmaceutically acceptable salt thereof, which is a compound represented by formula I. The compound has a potent inhibitory effect on immune cell migration. The compound itself has strong permeability and good water solubility, and can be used as an immune cell migration inhibitor for the development of drugs for treating ophthalmic diseases such as dry eye syndrome.[French]
L'invention concerne un dérivé d'amide de tétrahydroisoquinoléine trisubstituée ou un sel pharmaceutiquement acceptable de celui-ci, étant un composé représenté par la formule I. Le composé présente un puissant effet inhibiteur sur la migration des cellules immunitaires. Le composé lui-même présente une forte perméabilité et une bonne solubilité dans l'eau, et peut être utilisé en tant qu'inhibiteur de la migration des cellules immunitaires pour le développement de médicaments destinés au traitement de maladies ophtalmiques telles que le syndrome de l'œil sec.[Chinese]
提供一种三取代四氢异喹啉酰胺类衍生物或其药学上可接受的盐，为式Ⅰ所示的化合物。该化合物对免疫细胞迁徙有很强的抑制能力，化合物本身渗透性强，水溶性好，可以用作免疫细胞迁徙抑制剂，用于开发治疗干眼症等眼科疾病的药物。