WO2026052031 - CARBAZOLE DERIVATIVE AND USE THEREOF
National phase entry is expected:
Publication Number
WO/2026/052031
Publication Date
12.03.2026
International Application No.
PCT/CN2025/119168
International Filing Date
05.09.2025
Title **
[English]
CARBAZOLE DERIVATIVE AND USE THEREOF
[French]
DÉRIVÉ DE CARBAZOLE ET SON UTILISATION
[Chinese]
一类咔唑衍生物及用途
Applicants **
INSTITUTE OF MATERIA MEDICA ,CHINESE ACADEMY OF MEDICAL SCICENCES
Inventors
ZHANG, Dongming
PENG, Ying
ZANG, Yingda
TAO, Anhua
GONG, Shuang
KANG, Yuying
TANG, Jingshu
LAN, Jiaqi
QU, Kai
LUO, Haowen
ZHANG, Baodan
WU, Yi
PANG, Bo
HU, Haiyang
CHEN, Qiuyu
LI, Xinnan
ZHANG, Yiran
Priority Data
202411239267.6
05.09.2024
CN
202510345978.X
24.03.2025
CN
202510345977.5
24.03.2025
CN
202510345975.6
24.03.2025
CN
202510345973.7
24.03.2025
CN
202510345968.6
24.03.2025
CN
202510345966.7
24.03.2025
CN
202510345964.8
24.03.2025
CN
Application details
| Total Number of Claims/PCT | * |
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International Searching Authority |
CNIPA
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| Recordal of a Change of the Applicant's Name/Address |
Change of Applicant's Name and Address
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| Type of Assignment |
The Standard Agent's Assignment
* |
| Applicant's Legal Status |
Legal Entity
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| * | |
| * | |
| * | |
| * | |
| * | |
| Entry into National Phase under |
Chapter I
* |
| Patent Delivery |
Send the Letters Patent by Courier
* |
| 译文 |
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* The data is based on automatic recognition. Please verify and amend if necessary.
** IP-Coster compiles data from publicly available sources. If this data includes your personal information, you can contact us to request its removal.
Quotation for National Phase entry
| Country | Stages | Total | |
|---|---|---|---|
| China | Filing, Examination, Granting | 2469 | |
| EPO | Filing, Examination, Granting | 12954 | |
| Japan | Filing, Examination, Granting | 2155 | |
| South Korea | Filing, Examination, Granting | 2366 | |
| USA | Filing, Examination, Granting | 4740 |
Total:
24,684
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Abstract[English]
The present invention belongs to the technical field of medicine. Disclosed are a pyranocarbazole derivative and a preparation method therefor, and a pharmaceutical composition thereof and the use thereof. Specifically, disclosed in the present invention are pyranocarbazole derivatives as represented by general formulas I and II. The derivative is prepared by means of artificial synthesis. Further disclosed are a pharmaceutical composition containing the derivative, and the use thereof in resisting inflammation, resisting ischemic cerebral injury, relieving pain, resisting brain trauma, treating post-stroke depression, treating vascular dementia and cerebral small vessel disease, resisting Alzheimer's disease, and treating amyotrophic lateral sclerosis.[French]
La présente invention appartient au domaine technique de la médecine. L'invention concerne un dérivé de pyranocarbazole et son procédé de préparation, une composition pharmaceutique de celui-ci et son utilisation. Plus particulièrement, la présente invention concerne des dérivés de pyranocarbazole représentés par les formules générales I et II. Le dérivé est préparé par synthèse artificielle. L'invention concerne en outre une composition pharmaceutique contenant le dérivé, et son utilisation dans la résistance à l'inflammation, la résistance à une lésion cérébrale ischémique, le soulagement de la douleur, la résistance à un traumatisme cérébral, le traitement de la dépression post-accident vasculaire cérébral, le traitement de la démence vasculaire et de la microangiopathie cérébrale, la résistance à la maladie d'Alzheimer, et le traitement de la sclérose latérale amyotrophique.[Chinese]
本发明属于医药技术领域，公开了一类吡喃并咔唑衍生物及其制备方法和其药物组合物与用途。具体而言，本发明公开了如通式I和II所示的吡喃并咔唑衍生物。这类衍生物是通过人工合成的方式制备，含有其药物组合物，以及它们在抗炎、抗脑缺血损伤、镇痛、抗脑外伤、治疗卒中后抑郁、治疗血管性痴呆和脑小血管病、抗阿尔茨海默病以及治疗肌萎缩侧索硬化症方面的应用。