WO2025195505 - MEMBRANE-ASSOCIATED TYROSINE AND THREONINE KINASE INHIBITOR COMPOUND AND USE THEREOF

National phase entry is expected:
Publication Number WO/2025/195505
Publication Date 25.09.2025
International Application No. PCT/CN2025/084113
International Filing Date 21.03.2025
Title **
[English] MEMBRANE-ASSOCIATED TYROSINE AND THREONINE KINASE INHIBITOR COMPOUND AND USE THEREOF
[French] COMPOSÉ INHIBITEUR DES TYROSINE ET THRÉONINE KINASES ASSOCIÉES À LA MEMBRANE ET SON UTILISATION
[Chinese] 膜缔合酪氨酸和苏氨酸激酶抑制剂化合物及其应用
Applicants **
HAINAN SIMCERE ZAIMING PHARMACEUTICAL CO., LTD.
Inventors
ZHU, Dongxing
WANG, Tao
ZHOU, Yike
ZHU, Wei
LI, Zhengtao
TANG, Renhong
Priority Data
202410336501.0   22.03.2024   CN
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Quotation for National Phase entry

Country StagesTotal
China Filing, Examination, Granting1834
EPO Filing, Examination, Granting12359
Japan Filing, Examination, Granting2185
South Korea Filing, Examination, Granting2199
USA Filing, Examination, Granting4740
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Abstract[English] The present disclosure relates to a PKMYT1 inhibitor compound represented by formula (II') or a stereoisomer or pharmaceutically acceptable salt thereof, a preparation method therefor, a pharmaceutical composition containing the compound or a stereoisomer or pharmaceutically acceptable salt thereof, and the use of same in the prevention or treatment of PKMYT1-related diseases.[French] La présente invention concerne un composé inhibiteur de PKMYT1 représenté par la formule (II') ou un stéréoisomère ou un sel pharmaceutiquement acceptable de celui-ci, son procédé de préparation, une composition pharmaceutique contenant le composé ou un stéréoisomère ou un sel pharmaceutiquement acceptable de celui-ci, et son utilisation dans la prévention ou le traitement de maladies associées à PKMYT1.[Chinese] 本公开涉及式(II')所示PKMYT1抑制剂化合物或其立体异构体或其药学上可接受的盐、其制备方法、含有该化合物或其立体异构体或其药学上可接受的盐的药物组合物、以及其在预防或治疗PKMYT1相关疾病中的用途。