WO2025201136 - COMPOSITION AND USE THEREOF

National phase entry is expected:
Publication Number WO/2025/201136
Publication Date 02.10.2025
International Application No. PCT/CN2025/083436
International Filing Date 19.03.2025
Title **
[English] COMPOSITION AND USE THEREOF
[French] COMPOSITION ET SON UTILISATION
[Chinese] 组合物及其应用
Applicants **
NANJING NUTRABUILDING BIO-TECH CO., LTD.
Inventors
JIANG, Long
ZHU, Xi
WELLS, Shawn
LIAO, Kylin
Priority Data
PCT/CN2024/083552   25.03.2024   CN
PCT/CN2024/083564   25.03.2024   CN
PCT/CN2024/083586   25.03.2024   CN
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China Filing, Examination, Granting2086
EPO Filing, Examination, Granting15333
Japan Filing, Examination, Granting2371
South Korea Filing, Examination, Granting2668
USA Filing, Examination, Granting5140
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Abstract[English] A 3-hydroxybutyric acid/3-hydroxybutyrate composition, comprising a non-racemic mixture of R-3-hydroxybutyric acid/R-3-hydroxybutyrate of which the enantiomeric excess is greater than 50% and less than 100% and S-3-hydroxybutyric acid/S-3-hydroxybutyrate of which the enantiomeric excess is less than 50% and greater than 0%, or comprising a non-racemic mixture of S-3-hydroxybutyric acid/S-3-hydroxybutyrate of which the enantiomeric excess is greater than 50% and less than 100% and R-3-hydroxybutyric acid/R-3-hydroxybutyrate of which the enantiomeric excess is less than 50% and greater than 0%, the salt comprising sodium, potassium, magnesium, and calcium. The composition effectively solves acid/salt load and gastrointestinal side effects associated with existing products, offers excellent taste comfort and a good ketogenic effect, and can better serve as a dietary or nutritional supplement.[French] L'invention concerne une composition d'acide 3-hydroxybutyrique/3-hydroxybutyrate, comprenant un mélange non racémique d'acide R-3-hydroxybutyrique/R-3-hydroxybutyrate dont l'excès énantiomérique est supérieur à 50 % et inférieur à 100 % et d'acide S-3-hydroxybutyrique/S-3-hydroxybutyrate dont l'excès énantiomérique est inférieur à 50 % et supérieur à 0 %, ou comprenant un mélange non racémique d'acide S-3-hydroxybutyrique/S-3-hydroxybutyrate dont l'excès énantiomérique est supérieur à 50 % et inférieur à 100 % et d'acide R-3-hydroxybutyrique/R-3-hydroxybutyrate dont l'excès énantiomérique est inférieur à 50 % et supérieur à 0 %, le sel comprenant du sodium, du potassium, du magnésium et du calcium. La composition résout efficacement la charge acide/sel et les effets secondaires gastro-intestinaux associés aux produits existants, a bon goût et offre un bon effet cétogène, et peut mieux servir de complément alimentaire ou nutritionnel.[Chinese] 一种3-羟基丁酸·3-羟基丁酸盐组合物,包含大于50%且小于100%对映体当量的R-3-羟基丁酸·R-3-羟基丁酸盐和小于50%且大于0%对映体当量的S-3-羟基丁酸·S-3-羟基丁酸盐的非外消旋混合物,或包含大于50%且小于100%对映体当量的S-3-羟基丁酸·S-3-羟基丁酸盐和小于50%且大于0%对映体当量的R-3-羟基丁酸·R-3-羟基丁酸盐的非外消旋混合物,所述盐包括钠、钾、镁、钙。所述组合物有效解决了现有产品伴随的酸/盐负荷以及胃肠副作用,具有很好的口感舒适性,并且具有较好的生酮效果,可以更好的作为膳食或营养补充剂。