WO2025209007 - ALKYL DIAMINE-SUBSTITUTED BIS-AROMATIC HETEROCYCLIC THIOETHER COMPOUND, PREPARATION THEREOF, AND APPLICATION THEREOF IN PREPARATION OF DRUGS FOR TREATING AND/OR PREVENTING TUMORS
National phase entry is expected:
Publication Number
WO/2025/209007
Publication Date
09.10.2025
International Application No.
PCT/CN2025/074152
International Filing Date
23.01.2025
Title **
[English]
ALKYL DIAMINE-SUBSTITUTED BIS-AROMATIC HETEROCYCLIC THIOETHER COMPOUND, PREPARATION THEREOF, AND APPLICATION THEREOF IN PREPARATION OF DRUGS FOR TREATING AND/OR PREVENTING TUMORS
[French]
COMPOSÉ THIOÉTHER HÉTÉROCYCLIQUE BIS-AROMATIQUE SUBSTITUÉ PAR UNE DIAMINE ALKYLE, SA PRÉPARATION ET SON APPLICATION DANS LA PRÉPARATION DE MÉDICAMENTS POUR LE TRAITEMENT ET/OU LA PRÉVENTION DE TUMEURS
[Chinese]
一种烷基二胺取代双芳杂环基硫醚类化合物及其制备和在制备治疗和/或预防肿瘤药物中的应用
Applicants **
WANG, Chungang
Inventors
WANG, Chungang
Priority Data
202410390741.9
02.04.2024
CN
Application details
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International Searching Authority |
CNIPA
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| Recordal of a Change of the Applicant's Name/Address |
Change of Applicant's Name and Address
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| Type of Assignment |
The Standard Agent's Assignment
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| Applicant's Legal Status |
Natural Person
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| Entry into National Phase under |
Chapter I
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| Patent Delivery |
Send the Letters Patent by Courier
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| 译文 |
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Quotation for National Phase entry
| Country | Stages | Total | |
|---|---|---|---|
| China | Filing, Examination, Granting | 1728 | |
| EPO | Filing, Examination, Granting | 9012 | |
| Japan | Filing, Examination, Granting | 2030 | |
| South Korea | Filing, Examination, Granting | 1867 | |
| USA | Filing, Examination, Granting | 4740 |
Total:
19,377
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Abstract[English]
concentration of the compound against tumor cells, such as breast cancer, pancreatic cancer, lung cancer, glioma, ovarian cancer, esophageal cancer, melanoma, colon cancer, cervical cancer, is lower than cisplatin, and experiments show that the compound has broad-spectrum anti-tumor activity. Experiments have further detected that the compound exhibits the effect of degrading PD-L1 proteins, and is a PD-L1 immunomodulator. The present invention provides a new approach for using alkyl diamine-substituted bis-aromatic heterocyclic thioether compounds in the preparation of drugs for treating and/or preventing tumors.[French]
du composé contre des cellules tumorales, telles que le cancer du sein, le cancer du pancréas, le cancer du poumon, le gliome, le cancer de l'ovaire, le cancer de l'œsophage, le mélanome, le cancer du côlon, le cancer du col de l'utérus, étant inférieure à celle de la cisplatine, et des expériences montrent que le composé a une activité antitumorale à large spectre. Des expériences ont en outre détecté que le composé permettait de dégrader des protéines PD-L1 et était un immunomodulateur PD-L1. La présente invention concerne une nouvelle approche pour utiliser des composés thioéther hétérocycliques bis-aromatiques substitués par diamine d'alkyle dans la préparation de médicaments pour le traitement et/ou la prévention de tumeurs.[Chinese]
有效浓度低于顺铂，实验显示这类化合物具有广谱的抗肿瘤活性；实验还检测到这类化合物具有降解PD-L1蛋白的作用，是一种PD-L1免疫调节剂。本发明为烷基二胺取代双芳杂环基硫醚类化合物在制备治疗和/或预防肿瘤的药物应用提供新的途径。