WO2025152750 - BIS-HETEROCYCLIC WRN INHIBITOR, PREPARATION METHOD THEREFOR, AND USE THEREOF
National phase entry is expected:
Publication Number
WO/2025/152750
Publication Date
24.07.2025
International Application No.
PCT/CN2024/143010
International Filing Date
27.12.2024
Title **
[English]
BIS-HETEROCYCLIC WRN INHIBITOR, PREPARATION METHOD THEREFOR, AND USE THEREOF
[French]
INHIBITEUR DE WRN BIS-HÉTÉROCYCLIQUE, SON PROCÉDÉ DE PRÉPARATION ET SON UTILISATION
[Chinese]
双杂环WRN抑制剂、其制备方法及其应用
Applicants **
CHENGDU CHIPSCREEN PHARMACEUTICAL LTD.
Inventors
WANG, Wei
SUN, Xiaoyang
LIU, Ziqiang
LIU, Hang
LIU, Xiangkai
ZHANG, Jixin
QING, Ying
ZHANG, Ping
SHAN, Song
PAN, Desi
LU, Xianping
Priority Data
202410071031.X
17.01.2024
CN
202410173475.4
06.02.2024
CN
202410286328.8
13.03.2024
CN
202410437112.7
11.04.2024
CN
202410909880.8
05.07.2024
CN
Application details
| Total Number of Claims/PCT | * |
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| Number of Multi-Dependent Claims | * |
| Number of Drawings | * |
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| Pages of Specification | * |
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| Number of Office Actions | * |
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International Searching Authority |
CNIPA
* |
| Recordal of a Change of the Applicant's Name/Address |
Change of Applicant's Name and Address
* |
| Type of Assignment |
The Standard Agent's Assignment
* |
| Applicant's Legal Status |
Legal Entity
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| * | |
| * | |
| * | |
| * | |
| * | |
| Entry into National Phase under |
Chapter I
* |
| Patent Delivery |
Send the Letters Patent by Courier
* |
| 译文 |
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* The data is based on automatic recognition. Please verify and amend if necessary.
** IP-Coster compiles data from publicly available sources. If this data includes your personal information, you can contact us to request its removal.
Quotation for National Phase entry
| Country | Stages | Total | |
|---|---|---|---|
| China | Filing, Examination, Granting | 2905 | |
| EPO | Filing, Examination, Granting | 20090 | |
| Japan | Filing, Examination, Granting | 2524 | |
| South Korea | Filing, Examination, Granting | 3058 | |
| USA | Filing, Examination, Granting | 7790 |
Total:
36,367
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Abstract[English]
The present invention relates to a bis-heterocyclic WRN inhibitor represented by formula (I), a preparation method therefor, and a use thereof. The present invention also relates to a pharmaceutical composition comprising the compound as an active ingredient, and a use of the compound or the pharmaceutical composition in the treatment and/or prevention of diseases associated with the biological activity of WRN.[French]
La présente invention concerne un inhibiteur de WRN bis-hétérocyclique représenté par la formule (I), son procédé de préparation et son utilisation. La présente invention concerne également une composition pharmaceutique comprenant le composé en tant que principe actif et l'utilisation du composé ou de la composition pharmaceutique dans le traitement et/ou la prévention de maladies associées à l'activité biologique de WRN.[Chinese]
本发明涉及一种式(I)所示的双杂环WRN抑制剂、其制备方法及其应用。本发明还涉及包含所述化合物作为活性成分的药物组合物以及所述化合物或药物组合物用于治疗和/或预防与WRN生物学活性相关的疾病的用途。