WO2025124586 - DEGRADABLE CATIONIC LIPID CONTAINING DISULFIDE BOND AND USE THEREOF
National phase entry is expected:
Publication Number
WO/2025/124586
Publication Date
19.06.2025
International Application No.
PCT/CN2024/139424
International Filing Date
13.12.2024
Title **
[English]
DEGRADABLE CATIONIC LIPID CONTAINING DISULFIDE BOND AND USE THEREOF
[French]
LIPIDE CATIONIQUE DÉGRADABLE CONTENANT UNE LIAISON DISULFURE ET SON UTILISATION
[Chinese]
一种含二硫键的可降解阳离子脂质及其应用
Applicants **
XIAMEN SINOPEG BIOTECH CO., LTD
Inventors
LIN, Sheng
ZHU, Qi
CHEN, Dandan
WANG, Ailan
WEI, Guohua
WENG, Wengui
LIU, Chao
LIN, Minggui
Priority Data
202311726611.X
15.12.2023
CN
202410365740.9
28.03.2024
CN
Application details
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International Searching Authority |
CNIPA
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| Recordal of a Change of the Applicant's Name/Address |
Change of Applicant's Name and Address
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| Type of Assignment |
The Standard Agent's Assignment
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| Applicant's Legal Status |
Legal Entity
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| Entry into National Phase under |
Chapter I
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| Patent Delivery |
Send the Letters Patent by Courier
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| 译文 |
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Quotation for National Phase entry
| Country | Stages | Total | |
|---|---|---|---|
| China | Filing, Examination, Granting | 2657 | |
| EPO | Filing, Examination, Granting | 19414 | |
| Japan | Filing, Examination, Granting | 2494 | |
| South Korea | Filing, Examination, Granting | 2901 | |
| USA | Filing, Examination, Granting | 6390 |
Total:
33,856
The term for entry into the National Phase has expired. This quotation is for informational purposes only
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Abstract[English]
hydrocarbon derivative residue. A lipid composition prepared from the cationic lipid of the present invention can enable an LNP-nucleic acid pharmaceutical composition preparation to more fully exert a drug effect on the premise of having good capability for compounding a nucleic acid and a drug, in-vivo stability and low toxicity, thereby improving the immune or treatment effect.[French]
substitué ou non substitué. Une composition lipidique préparée à partir du lipide cationique selon la présente invention peut permettre une meilleure efficacité thérapeutique d'une préparation de composition pharmaceutique LNP-acide nucléique, tout en présentant une bonne capacité à complexer un acide nucléique et un médicament, avec une stabilité in vivo et une faible toxicité, ce qui permet d'améliorer l'effet immunitaire ou thérapeutique.[Chinese]
烃衍生物残基。用本发明的阳离子脂质制备的脂质组合物，在具备良好的核酸药物复合能力、体内稳定性和低毒性的前提下，能够使LNP-核酸药物组合物制剂更加充分地发挥药效，提高免疫或治疗效果。