WO2026113062 - UNIVERSAL UTR SEQUENCES FOR MRNA ASSEMBLY, COMPOSITION THEREOF, AND USE THEREOF
National phase entry is expected:
Publication Number
WO/2026/113062
Publication Date
04.06.2026
International Application No.
PCT/CN2024/138492
International Filing Date
11.12.2024
Title **
[English]
UNIVERSAL UTR SEQUENCES FOR MRNA ASSEMBLY, COMPOSITION THEREOF, AND USE THEREOF
[French]
SÉQUENCES UTR UNIVERSELLES POUR L'ASSEMBLAGE D'ARNM, COMPOSITION LES CONTENANT ET UTILISATION ASSOCIÉE
[Chinese]
用于组装mRNA的通用UTRs序列、其组合物及其应用
Applicants **
CHENGDU NUOEN BIOTECHNOLOGY CO., LTD
Inventors
XU, Kai
YIN, Hailin
WU, Xiujin
LEI, Yingxue
CHEN, Liang
ZHANG, Yaoyi
YANG, Jian
TANG, Huan
Priority Data
202411722913.4
28.11.2024
CN
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International Searching Authority |
CNIPA
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The Standard Agent's Assignment
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Legal Entity
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| Entry into National Phase under |
Chapter I
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Quotation for National Phase entry
| Country | Stages | Total | |
|---|---|---|---|
| China | Filing, Examination, Granting | 1576 | |
| EPO | Filing, Examination, Granting | 11576 | |
| Japan | Filing, Examination, Granting | 2001 | |
| South Korea | Filing, Examination, Granting | 1805 | |
| USA | Filing, Examination, Granting | 4740 |
Total:
21,698
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Abstract[English]
Disclosed are universal UTR sequences for mRNA assembly, a composition thereof, and use thereof, belonging to the fields of molecular biology and biotechnology. The sequences are obtained by modifying a 5'UTR sequence and/or a 3'UTR sequence, for example, adding GCCACC at position -1 or adding GCCACC at position -4 of a consensus sequence of the 5'UTR, removing a uORF from the 5'UTR, and adding three sets of stop codons at the 5' end. The provided universal modified 5'UTR and 3'UTR sequences can effectively promote the stability and protein expression level of mRNAs, and are particularly suitable for the fields of gene therapy and therapeutic protein production.[French]
La présente invention concerne des séquences UTR universelles destinées à l'assemblage d'ARNm, une composition les contenant et l'utilisation associée, relevant des domaines de la biologie moléculaire et de la biotechnologie. Ces séquences sont obtenues en modifiant une séquence de l'UTR 5' et/ou une séquence de l'UTR 3', par exemple en ajoutant GCCACC au niveau de la position -1 ou en ajoutant GCCACC au niveau de la position -4 d'une séquence consensus de l'UTR 5', en supprimant un uORF de l'UTR 5' et en ajoutant trois séries de codons d'arrêt à l'extrémité 5'. Les séquences universelles modifiées de l'UTR 5' et de l'UTR 3' selon la présente invention favorisent efficacement la stabilité et l'expression de protéines des ARNm ; elles sont plus particulièrement adaptées aux domaines de la thérapie génique et de la production de protéines thérapeutiques.[Chinese]
公开了一种用于组装mRNA的通用UTRs序列、其组合物及其应用，属于分子生物学和生物技术领域，所述序列是对5'UTR序列和/或3'UTR序列进行修饰，比如在5'UTR 的共识序列的-1位加入GCCACC，或在-4位加入GCCACC，从5'UTR中移除uORF，并在5'端加入3组终止密码；提供的通用型修饰5'UTR和3'UTR序列可有效促进mRNA的稳定性和蛋白表达水平，特别适用于基因治疗及治疗性蛋白质生产等领域。