WO2025026283 - COMPOUND FOR SELECTIVELY DEGRADING SMARCA2/4 AND USE THEREOF
National phase entry is expected:
Publication Number
WO/2025/026283
Publication Date
06.02.2025
International Application No.
PCT/CN2024/108262
International Filing Date
29.07.2024
Title **
[English]
COMPOUND FOR SELECTIVELY DEGRADING SMARCA2/4 AND USE THEREOF
[French]
COMPOSÉ POUR DÉGRADER SÉLECTIVEMENT SMARCA2/4 ET SON UTILISATION
[Chinese]
一种选择性降解SMARCA2/4的化合物及其应用
Applicants **
GAN & LEE PHARMACEUTICALS CO., LTD.
Inventors
XU, Fuming
CHEN, Wenmin
LI, Xiaoguang
DING, Yongzheng
ZHOU, Guan
GU, Siyu
Priority Data
202310939545.8
28.07.2023
CN
202410864991.1
01.07.2024
CN
Application details
| Total Number of Claims/PCT | * |
| Number of Independent Claims | * |
| Number of Priorities | * |
| Number of Multi-Dependent Claims | * |
| Number of Drawings | * |
| Pages for Publication | * |
| Number of Pages with Drawings | * |
| Pages of Specification | * |
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| Number of Office Actions | * |
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International Searching Authority |
CNIPA
* |
| Recordal of a Change of the Applicant's Name/Address |
Change of Applicant's Name and Address
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| Type of Assignment |
The Standard Agent's Assignment
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| Applicant's Legal Status |
Legal Entity
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| * | |
| * | |
| * | |
| * | |
| * | |
| Entry into National Phase under |
Chapter I
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| Patent Delivery |
Send the Letters Patent by Courier
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| 译文 |
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Quotation for National Phase entry
| Country | Stages | Total | |
|---|---|---|---|
| China | Filing, Examination, Granting | 3209 | |
| EPO | Filing, Examination, Granting | 18382 | |
| Japan | Filing, Examination, Granting | 2247 | |
| South Korea | Filing, Examination, Granting | 2369 | |
| USA | Filing, Examination, Granting | 6090 |
Total:
32,297
The term for entry into the National Phase has expired. This quotation is for informational purposes only
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Abstract[English]
The present disclosure relates to a compound capable of being used as a SMARCA2/4 modulator. Specifically, the compound involved in the present disclosure contains a ligand at one end that binds to an E3 ubiquitin ligase, and contains a ligand at the other end that binds to a target protein (SMARCA2/4), such that the target protein is placed in the vicinity of the ubiquitin ligase, so as to achieve the degradation (or inhibition) of the target protein.[French]
La présente divulgation concerne un composé pouvant être utilisé en tant que modulateur de SMARCA2/4. Spécifiquement, le composé impliqué dans la présente divulgation contient un ligand à une extrémité qui se lie à une ubiquitine ligase E3, et contient un ligand à l'autre extrémité qui se lie à une protéine cible (SMARCA2/4), de telle sorte que la protéine cible est placée à proximité de l'ubiquitine ligase, de façon à obtenir la dégradation (ou l'inhibition) de la protéine cible.[Chinese]
本公开涉及可用作SMARCA2/4调节剂的化合物。具体地讲，本公开所涉及到的化合物在一端上含有结合E3泛素连接酶的配体，并且在另一端上含有结合靶蛋白(SMARCA2/4)的配体，使得所述靶蛋白被置于所述泛素连接酶附近，以实现靶蛋白的降解(或抑制)。