WO2022078524 - SPECIFIC CONJUGATION OF AN ANTIBODY
National phase entry:
Publication Number
WO/2022/078524
Publication Date
21.04.2022
International Application No.
PCT/CN2021/128453
International Filing Date
03.11.2021
Title **
[English]
SPECIFIC CONJUGATION OF AN ANTIBODY
[French]
CONJUGAISON SPÉCIFIQUE D'UN ANTICORPS
Applicants **
HANGZHOU DAC BIOTECH CO., LTD.
Inventors
ZHAO, Robert
YANG, Qingliang
LIU, Xiaolei
ZHANG, Lingli
HUANG, Yuanyuan
LI, Wenjun
YE, Hangbo
WANG, Juan
GUO, Huihui
ZHOU, You
Application details
| Total Number of Claims/PCT | * |
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| Number of Multi-Dependent Claims | * |
| Number of Drawings | * |
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International Searching Authority |
CNIPA
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| Recordal of a Change of the Applicant's Name/Address |
Change of Applicant's Name and Address
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| Type of Assignment |
The Standard Agent's Assignment
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| Applicant's Legal Status |
Legal Entity
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| Entry into National Phase under |
Chapter I
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| Patent Delivery |
Send the Letters Patent by Courier
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| 译文 |
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Quotation for National Phase entry
| Country | Stages | Total | |
|---|---|---|---|
| China | Filing, Examination, Granting | 9577 | |
| EPO | Filing, Examination, Granting | 32466 | |
| Japan | Filing, Examination, Granting | 1610 | |
| South Korea | Filing, Examination, Granting | 1015 | |
| USA | Filing, Examination, Granting | 7090 |
Total:
51,758
The term for entry into the National Phase has expired. This quotation is for informational purposes only
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Abstract[English]
Provided herein is a process for preparing a homogeneous conjugate of an antibody or antibody-like protein via linkage of cysteine sites between heavy-light chains in the IgG antibody or antibody-like protein. It also relates to methods of making the conjugates in a specific manner comprising either generation of specific thiols of an antibody or antibody-like protein agent, followed by reaction with drug/linker complexes, or generation of specific thiols of an antibody or antibody-like protein agent and conjugation of a synthetic linker-drug assembly with the thiols simultaneously in one pot reaction, to provide conjugates with over 75%, in most cases more than 80% of payloads linked at the specific cysteine sites between heavy-light chains of the IgG antibody or antibody-like protein. It also relates to methods of using the homogeneous conjugate in targeted prophylaxis or treatment of cancer, infection and immunological disorders.[French]
L'invention concerne un procédé de préparation d'un conjugué homogène d'un anticorps ou d'une protéine de type anticorps par liaison de sites de cystéine entre des chaînes légères-lourdes dans l'anticorps IgG ou la protéine de type anticorps. La présente invention concerne également des procédés de fabrication des conjugués d'une manière spécifique comprenant soit la génération de thiols spécifiques d'un anticorps ou d'un agent de protéine de type anticorps, suivie d'une réaction avec des complexes médicament/lieur, soit la génération de thiols spécifiques d'un anticorps ou d'un agent de protéine de type anticorps et la conjugaison d'un ensemble lieur synthétique-médicament avec les thiols simultanément dans une réaction monotope, pour obtenir des conjugués avec plus de 75 %, dans la plupart des cas plus de 80 % de charges utiles liées au niveau des sites de cystéine spécifiques entre des chaînes légères-lourdes de l'anticorps IgG ou de la protéine de type anticorps. L'invention concerne également des procédés d'utilisation du conjugué homogène dans la prophylaxie ou le traitement ciblé du cancer, d'une infection et de troubles immunologiques.