WO2025255537 - DOUBLE-TAPERED SLOPED MICROSTRUCTURES WITH EMBEDDED MICROCHANNEL ARRAYS FOR TISSUE BARRIER FORMATION ON ORGAN-ON-CHIP PLATFORMS
National phase entry is expected:
Publication Number
WO/2025/255537
Publication Date
11.12.2025
International Application No.
PCT/US2025/032757
International Filing Date
06.06.2025
Title **
[English]
DOUBLE-TAPERED SLOPED MICROSTRUCTURES WITH EMBEDDED MICROCHANNEL ARRAYS FOR TISSUE BARRIER FORMATION ON ORGAN-ON-CHIP PLATFORMS
[French]
MICROSTRUCTURES À DOUBLE INCLINAISON BICONIQUE AVEC RÉSEAUX DE MICROCANAUX INTÉGRÉS POUR FORMATION DE BARRIÈRE TISSULAIRE SUR DES PLATEFORMES D'ORGANE SUR PUCE
Applicants **
THE TEXAS A&M UNIVERSITY SYSTEM
Inventors
HAN, Arum
LAM, Po, Yi
Priority Data
63/657,111
06.06.2024
US
Application details
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International Searching Authority |
USPTO
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| Recordal of a Change of the Applicant's Name/Address |
Change of Applicant's Name and Address
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| Type of Assignment |
The Standard Agent's Assignment
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| Applicant's Legal Status |
Legal Entity
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| Entry into National Phase under |
Chapter I
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| Patent Delivery |
Send the Letters Patent by Courier
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| Translation |
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Quotation for National Phase entry
| Country | Stages | Total | |
|---|---|---|---|
| China | Filing, Examination, Granting | 2243 | |
| EPO | Filing, Examination, Granting | 14118 | |
| Japan | Filing, Examination, Granting | 2327 | |
| South Korea | Filing, Examination, Granting | 2432 | |
| USA | Filing, Examination, Granting | 4310 |
Total:
25,430
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Abstract[English]
An organ-on-chip model includes a first double-sloped microchannel device having a pair of oppositely disposed sloped surfaces, a plurality of microchannels integrated into each sloped surface of the pair of sloped surfaces, wherein the plurality of microchannels being in fluid communication with one another. The organ-on-chip model further includes a pair of cell culture compartments disposed on opposite sides of the first double-sloped microchannel device. The organ-on-chip model is configured to allow cells to attach on top of the pair of sloped surfaces and enable barrier formation to recapitulate tissue barrier function, and the plurality of microchannels are sized to prevent cells from freely moving between the pair of cell culture compartments during cell loading process, and to allow for molecules to diffuse through and allow active cell migration between the pair of cell culture compartments.[French]
Modèle d'organe sur puce comprenant un premier dispositif à microcanaux à double inclinaison ayant une paire de surfaces inclinées agencées de manière opposée, une pluralité de microcanaux intégrés dans chaque surface inclinée de la paire de surfaces inclinées, la pluralité de microcanaux étant en communication fluidique les uns avec les autres. Le modèle d'organe sur puce comprend en outre une paire de compartiments de culture cellulaire agencés sur des côtés opposés du premier dispositif à microcanaux à double inclinaison. Le modèle d'organe sur puce est conçu pour permettre à des cellules de se fixer au-dessus de la paire de surfaces inclinées et permettre la formation d'une barrière pour résumer la fonction de barrière tissulaire ; et la pluralité de microcanaux sont dimensionnés pour empêcher des cellules de se déplacer librement entre la paire de compartiments de culture cellulaire pendant le processus de chargement de cellules, ainsi que pour permettre à des molécules de se diffuser à travers et permettre une migration de cellules actives entre la paire de compartiments de culture cellulaire.