WO2025101438 - METHODS FOR DETECTING RHD INCOMPATIBILTY IN PREGNANT BLOOD AND PLASMA SAMPLES
National phase entry:
Publication Number
WO/2025/101438
Publication Date
15.05.2025
International Application No.
PCT/US2024/054233
International Filing Date
01.11.2024
Title **
[English]
METHODS FOR DETECTING RHD INCOMPATIBILTY IN PREGNANT BLOOD AND PLASMA SAMPLES
[French]
PROCÉDÉS DE DÉTECTION D'INCOMPATIBILITÉ RHD DANS DES ÉCHANTILLONS SANGUINS ET PLASMATIQUES DE FEMMES ENCEINTES
Applicants **
NATERA, INC.
Inventors
WANG, Xiaoke
WANG, Ting
BABIARZ, Joshua
PAWAR, Hemant
Priority Data
63/547,906
09.11.2023
US
63/602,023
22.11.2023
US
Application details
| Total Number of Claims/PCT | * |
| Number of Independent Claims | * |
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International Searching Authority |
EPO
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| Recordal of a Change of the Applicant's Name/Address |
Change of Applicant's Name and Address
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| Type of Assignment |
The Standard Agent's Assignment
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| Applicant's Legal Status |
Legal Entity
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| Entry into National Phase under |
Chapter I
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| Patent Delivery |
Send the Letters Patent by Courier
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| Translation |
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Quotation for National Phase entry
| Country | Stages | Total | |
|---|---|---|---|
| China | Filing, Examination, Granting | 2938 | |
| EPO | Filing, Examination, Granting | 20899 | |
| Japan | Filing, Examination, Granting | 2969 | |
| South Korea | Filing, Examination, Granting | 3637 | |
| USA | Filing, Examination, Granting | 10140 |
Total:
40,583
The term for entry into the National Phase has expired. This quotation is for informational purposes only
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Abstract[English]
Disclosed herein includes a method of detecting RhD incompatibility during pregnancy, comprising: a) extracting DNA from a blood sample of a pregnant mother; b) performing qPCR on the DNA to determine Ct values of at least one RhD exon and at least one internal control gene; and c) calculating a ΔCt value between the at least one RhD exon and at least one internal control gene.[French]
La présente invention comprend un procédé de détection d'une incompatibilité RhD pendant la grossesse, comportant les étapes suivantes : a) extraction de l'ADN d'un échantillon sanguin d'une mère enceinte ; b) réalisation d'une qPCR sur l'ADN pour déterminer les valeurs Ct d'au moins un exon RhD et d'au moins un gène témoin interne ; et c) calcul d'une valeur ΔCt entre au moins un exon RhD et au moins un gène témoin interne.