WO2025063927 - A BILAYER TABLET COMPRISING SACUBITRIL AND VALSARTAN

National phase entry:
Publication Number WO/2025/063927
Publication Date 27.03.2025
International Application No. PCT/TR2024/051041
International Filing Date 09.09.2024
Title **
[English] A BILAYER TABLET COMPRISING SACUBITRIL AND VALSARTAN
[French] COMPRIMÉ BICOUCHE COMPRENANT DU SACUBITRIL ET DU VALSARTAN
Applicants **
SANOVEL ILAC SANAYI VE TICARET ANONIM SIRKETI
Inventors
SUNEL, Fatih
ATAK, Fadime Bilgehan
KARABULUT, Serif
YUCEL, Alpay
Priority Data
2023/011672   20.09.2023   TR
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Quotation for National Phase entry

Country StagesTotal
China Filing, Examination, Granting2094
EPO Filing, Examination, Granting9203
Japan Filing, Examination, Granting2172
South Korea Filing, Examination, Granting2102
USA Filing, Examination, Granting4740
MasterCard Visa
Total: 20,311

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Abstract[English] The present invention relates to a bilayer tablet comprising first layer comprising sacubitril or a pharmaceutically acceptable salt thereof, at least one filler and second layer comprising valsartan or a pharmaceutically acceptable salt thereof, at least one filler wherein the weight ratio of filler(s) at first layer to filler(s) at second layer is between 0.5 and 2.5. The bilayer tablet having the desired dissolution profile and a long-term stability.[French] La présente invention concerne un comprimé bicouche comprenant une première couche qui comprend du sacubitril ou un sel pharmaceutiquement acceptable de celui-ci, au moins une charge et une seconde couche qui comprend du valsartan ou un sel pharmaceutiquement acceptable de celui-ci, au moins une charge, le rapport pondéral de la ou des charges au niveau de la première couche sur la ou les charges au niveau de la seconde couche étant compris entre 0,5 et 2,5. Le comprimé bicouche présente le profil de dissolution souhaité et une stabilité à long terme.

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