WO2025151088 - CATF) (AMINO ACID RESIDUES 11 TO 30) SELECTED BY BIOPANNING FROM THE MURINE NAÏVE SINGLE-CHAIN VARIABLE FRAGMENTS (SCFV) LIBRARY WITH THE PRODUCTION PROCEDURES
National phase entry is expected:
Publication Number
WO/2025/151088
Publication Date
17.07.2025
International Application No.
PCT/TH2024/000012
International Filing Date
30.08.2024
Title **
[English]
CATF) (AMINO ACID RESIDUES 11 TO 30) SELECTED BY BIOPANNING FROM THE MURINE NAÏVE SINGLE-CHAIN VARIABLE FRAGMENTS (SCFV) LIBRARY WITH THE PRODUCTION PROCEDURES
[French]
ANTICORPS À FRAGMENT VARIABLE SIMPLE CHAÎNE (SCFV) DE SOURIS RECONNAISSANT SPÉCIFIQUEMENT L'ÉPITOPE SUR LA PROTÉINE F DE CATHEPSINE DE DOUVE DU FOIE OPISTHORCHIS VIVERRINA (OVCATF) HUMAINE (RÉSIDUS D'ACIDE AMINÉ 11 À 10) SÉLECTIONNÉ PAR BIOPANNING À PARTIR DE BANQUES DE FRAGMENTS VARIABLES SIMPLE CHAÎNE (SCFV) NAÏFS MURINS ET PROCÉDURES DE PRODUCTION ASSOCIÉES
Applicants **
THAMMASAT UNIVERSITY
Inventors
MARTVISET, Pongsakorn
CHANTREE, Pathanin
THANONGSAKSRIKUL, Jeeraphong
SRIMANOTE, Potjanee
Priority Data
2401000241
12.01.2024
TH
Application details
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International Searching Authority |
USPTO
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| Recordal of a Change of the Applicant's Name/Address |
Change of Applicant's Name and Address
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| Type of Assignment |
The Standard Agent's Assignment
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| Applicant's Legal Status |
Legal Entity
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| Entry into National Phase under |
Chapter I
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| Patent Delivery |
Send the Letters Patent by Courier
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| Translation |
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Quotation for National Phase entry
| Country | Stages | Total | |
|---|---|---|---|
| China | Filing, Examination, Granting | 1955 | |
| EPO | Filing, Examination, Granting | 11598 | |
| Japan | Filing, Examination, Granting | 1952 | |
| South Korea | Filing, Examination, Granting | 1664 | |
| USA | Filing, Examination, Granting | 7310 |
Total:
24,479
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Abstract[English]
), which are connected by a disulfide bond to form a single chain. The scFv sequence from N- to C-terminus is "PWRRCSWRSLEEACVQPGDSLRLSCATSGFAFTDYYMNWVRQPPGKALEWLGFIRNKANGYTTEYSASVKGRFTISRDHSQSILYLQMNTLRAEDSATYYCARDIPSMDYWGQGTSVTVSSAKTTPPKLEEGEFSEARVDIVMTQAAPSVPVTPGESVSTSCRSSKSLLHSNGNTYLYWSLQRPGQSPQLLIYRMSNLASGVPDRFSGSGSGTAFTLRISRVEAEDVGVYYCMQHLEYPYTFGGGTKLEIKRADAAPTVSAAA" This scFv antibody is selected by biopanning from the murine naïve single-chain variable fragments (scFv) library and produced by recombinant protein technologies. The ultimate objective of this invention is to develop an effective diagnostic tool for opisthorchiasis and cholangiocarcinoma in the future.