WO2023228182 - SYSTEM AND METHODS FOR IMMUNE CELLS EXPANSION AND ACTIVATION IN LARGE SCALE
National phase entry:
Publication Number
WO/2023/228182
Publication Date
30.11.2023
International Application No.
PCT/IL2023/050529
International Filing Date
23.05.2023
Title **
[English]
SYSTEM AND METHODS FOR IMMUNE CELLS EXPANSION AND ACTIVATION IN LARGE SCALE
[French]
SYSTÈME ET PROCÉDÉS POUR LA MULTIPLICATION ET L'ACTIVATION DE CELLULES IMMUNITAIRES À GRANDE ÉCHELLE
Applicants **
PLURI BIOTECH LTD.
Inventors
RAVIV, Lior
BACHAR, Shirley
ROBERMAN, Dorina
Priority Data
63/344,780
23.05.2022
US
Application details
| Total Number of Claims/PCT | * |
| Number of Independent Claims | * |
| Number of Priorities | * |
| Number of Multi-Dependent Claims | * |
| Number of Drawings | * |
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| Number of Pages with Drawings | * |
| Pages of Specification | * |
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| Number of Office Actions | * |
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International Searching Authority |
ILPO
* |
| Recordal of a Change of the Applicant's Name/Address |
Change of Applicant's Name and Address
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| Type of Assignment |
The Standard Agent's Assignment
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| Applicant's Legal Status |
Legal Entity
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| * | |
| * | |
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| * | |
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| Entry into National Phase under |
Chapter I
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| Patent Delivery |
Send the Letters Patent by Courier
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| Translation |
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* The data is based on automatic recognition. Please verify and amend if necessary.
** IP-Coster compiles data from publicly available sources. If this data includes your personal information, you can contact us to request its removal.
Quotation for National Phase entry
| Country | Stages | Total | |
|---|---|---|---|
| China | Filing, Examination, Granting | 2399 | |
| EPO | Filing, Examination, Granting | 14091 | |
| Japan | Filing, Examination, Granting | 2290 | |
| South Korea | Filing, Examination, Granting | 2280 | |
| USA | Filing, Examination, Granting | 4740 |
Total:
25,800
The term for entry into the National Phase has expired. This quotation is for informational purposes only
Abstract[English]
This invention discloses a three-dimensional (3D) bioreactor for large scale expansion of immune cells and methods of use. The 3D bioreactor comprising at least one packed bed chamber comprising at least one porous scaffold; at least one porous scaffold coated with one or more extra cellular matrix protein (ECM); at least one container comprising a fluid media, the fluid media is configured to flow through said packed bed chamber with at least one porous coated scaffold; and at least one population of immune cells suspended in the fluid media, wherein, the at least one porous scaffold coated with said ECM is creates a stationary niche having low shear forces that imitate the natural growth environment of the immune cells and allows expansion of the immune cells population that flow through the coated porous scaffold in large scale.[French]
La présente invention concerne un bioréacteur tridimensionnel (3D) pour la multiplication à grande échelle de cellules immunitaires et des procédés d'utilisation. Le bioréacteur 3D comprend au moins une chambre à lit compact comprenant au moins un échafaudage poreux ; au moins un échafaudage poreux revêtu d'une ou plusieurs protéines de matrice extracellulaire (ECM) ; au moins un conteneur comprenant un milieu fluide, le milieu fluide est conçu pour s'écouler à travers ladite chambre à lit compact avec au moins un échafaudage poreux revêtu ; et au moins une population de cellules immunitaires en suspension dans le milieu fluide, dans lequel au moins un échafaudage poreux revêtu de ladite ECM crée une niche stationnaire présentant de faibles forces de cisaillement qui imitent l'environnement de croissance naturel des cellules immunitaires et permet la multiplication de la population de cellules immunitaires qui s'écoulent à travers l'échafaudage poreux revêtu à grande échelle.