WO2026146374 - ALPHA-AMYLASE VARIANTS WITH IMPROVED ACTIVITY
National phase entry is expected:
Publication Number
WO/2026/146374
Publication Date
09.07.2026
International Application No.
PCT/IB2025/063272
International Filing Date
19.12.2025
Title **
[English]
ALPHA-AMYLASE VARIANTS WITH IMPROVED ACTIVITY
[French]
VARIANTS D'ALPHA-AMYLASE À ACTIVITÉ AMÉLIORÉE
Applicants **
DANSTAR FERMENT AG
Inventors
SKINNER, Ryan
CALCINES-CRUZ, Carlos
PANAITIU, Alexandra Elena
PARADISE, Alexander
PRIVETT, Britney
SULLIVAN, Ian
Priority Data
63/740,120
30.12.2024
US
Application details
| Total Number of Claims/PCT | * |
| Number of Independent Claims | * |
| Number of Priorities | * |
| Number of Multi-Dependent Claims | * |
| Number of Drawings | * |
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| Pages of Specification | * |
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| Number of Office Actions | * |
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International Searching Authority |
EPO
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| Recordal of a Change of the Applicant's Name/Address |
Change of Applicant's Name and Address
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| Type of Assignment |
The Standard Agent's Assignment
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| Applicant's Legal Status |
Legal Entity
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| * | |
| * | |
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| Entry into National Phase under |
Chapter I
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| Patent Delivery |
Send the Letters Patent by Courier
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| Translation |
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Quotation for National Phase entry
| Country | Stages | Total | |
|---|---|---|---|
| China | Filing, Examination, Granting | 3530 | |
| EPO | Filing, Examination, Granting | 22384 | |
| Japan | Filing, Examination, Granting | 2843 | |
| South Korea | Filing, Examination, Granting | 3399 | |
| USA | Filing, Examination, Granting | 11040 |
Total:
43,196
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Abstract[English]
The present disclosure concerns an alpha-amylase variant having at least 70% identity with the amino acid sequence of SEQ ID NO: 2, and comprising an amino acid substitution at any one of positions 3, 4, 5, 8, 18, 24, 26, 33, 43, 70, 71, 79, 80, 84, 86, 91, 93, 96, 103, 105, 106, 117, 119, 123, 124, 125, 132, 133, 141, 143, 148, 151, 152, 155, 157, 158, 168, 174, 178, 181, 5 183, 185, 204, 207, 208, 209, 211, 219, 230, 233, 242, 246, 252, 261, 268, 273, 290, 301, 319, 327, 334, 336, 338, 343, 345, 347, 348, 357, 369, 372, 373, 380, 383, 385, 386, 393, 396, 397, 402, 407, 408, 415, 416, 422, 423, 426, and/or 442 as well as fusion polypeptides comprising same. The alpha-amylase variants or the fusion polypeptides can be used to hydrolyze starch.[French]
La présente divulgation concerne un variant d'alpha-amylase présentant au moins 70 % d'identité avec la séquence d'acides aminés de SEQ ID NO : 2, et comprenant une substitution d'acide aminé en l'une quelconque des positions 3, 4, 5, 8, 18, 24, 26, 33, 43, 70, 71, 79, 80, 84, 86, 91, 93, 96, 103, 105, 106, 117, 119, 123, 124, 125, 132, 133, 141, 143, 148, 151, 152, 155, 157, 158, 168, 174, 178, 181, 5 183, 185, 204, 207, 208, 209, 211, 219, 230, 233, 242, 246, 252, 261, 268, 273, 290, 301, 319, 327, 334, 336, 338, 343, 345, 347, 348, 357, 369, 372, 373, 380, 383, 385, 386, 393, 396, 397, 402, 407, 408, 415, 416, 422, 423, 426 et/ou 442 ainsi que des polypeptides de fusion les comprenant. Les variants d'alpha-amylase ou les polypeptides de fusion peuvent être utilisés pour hydrolyser l'amidon.