WO2026133250 - COMBINATIONS OF ANTISENSE AGENTS, PHARMACEUTICAL COMPOSITIONS AND METHODS OF USE
National phase entry is expected:
Publication Number
WO/2026/133250
Publication Date
25.06.2026
International Application No.
PCT/IB2025/063176
International Filing Date
18.12.2025
Title **
[English]
COMBINATIONS OF ANTISENSE AGENTS, PHARMACEUTICAL COMPOSITIONS AND METHODS OF USE
[French]
COMBINAISONS D'AGENTS ANTISENS, COMPOSITIONS PHARMACEUTIQUES ET MÉTHODES D'UTILISATION
Applicants **
NOVARTIS AG
Inventors
BROUSSEAU, Margaret Elizabeth
COUGHLIN, Shaun Robert
HAEMMIG, Stefan
HAGEN, Caitlin Jeanette
HUNZIKER, Juerg
HUANG, Zhihong
TAN, Ge
TRAUGER, John Wesley
WEILER, Jan
Priority Data
63/737,052
20.12.2024
US
Application details
| Total Number of Claims/PCT | * |
| Number of Independent Claims | * |
| Number of Priorities | * |
| Number of Multi-Dependent Claims | * |
| Number of Drawings | * |
| Pages for Publication | * |
| Number of Pages with Drawings | * |
| Pages of Specification | * |
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| Number of Office Actions | * |
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International Searching Authority |
EPO
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| Recordal of a Change of the Applicant's Name/Address |
Change of Applicant's Name and Address
* |
| Type of Assignment |
The Standard Agent's Assignment
* |
| Applicant's Legal Status |
Legal Entity
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| * | |
| * | |
| * | |
| * | |
| * | |
| Entry into National Phase under |
Chapter I
* |
| Patent Delivery |
Send the Letters Patent by Courier
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| Translation |
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* The data is based on automatic recognition. Please verify and amend if necessary.
** IP-Coster compiles data from publicly available sources. If this data includes your personal information, you can contact us to request its removal.
Quotation for National Phase entry
| Country | Stages | Total | |
|---|---|---|---|
| China | Filing, Examination, Granting | 8815 | |
| EPO | Filing, Examination, Granting | 60397 | |
| Japan | Filing, Examination, Granting | 3820 | |
| South Korea | Filing, Examination, Granting | 5313 | |
| USA | Filing, Examination, Granting | 28140 |
Total:
106,485
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Abstract[English]
Disclosed are, inter alia, combinations comprising a first antisense (e.g., first double stranded RNAi (dsRNAi)) agent for inhibiting expression of proprotein convertase subtilisin kexin 9 (PCSK9), for example, human PCSK9, and a second antisense agent (e.g., second dsRNAi agent) for inhibiting expression of 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR); pharmaceutical compositions including the same, and methods of treatment using the same.[French]
L'invention concerne, entre autres, des combinaisons comprenant un premier agent antisens (par exemple, un premier agent ARNi double brin (dsRNAi)) destiné à inhiber l'expression de la pro-protéine subtilisine kexine convertase de type 9 (PCSK9), par exemple, PCSK9 humaine, et un second agent antisens (par exemple, un second agent dsRNAi) destiné à inhiber l'expression de la 3-hydroxy-3-méthylglutaryl-CoA réductase (HMGCR) ; des compositions pharmaceutiques les comprenant, et des méthodes de traitement les utilisant.