WO2026120486 - SOLUBLE HYALURONIDASE AND PRODUCTION THEREOF
National phase entry:
Publication Number
WO/2026/120486
Publication Date
11.06.2026
International Application No.
PCT/IB2025/062338
International Filing Date
02.12.2025
Title **
[English]
SOLUBLE HYALURONIDASE AND PRODUCTION THEREOF
[French]
HYALURONIDASE SOLUBLE ET SA PRODUCTION
Applicants **
HALOZYME, INC.
Inventors
ZUNIGA, Jose
GRANT, Carolynn
DERUNES, Celine
LEE, Alice
CHEN, Leo
LEANG, Valerine
PUTNAM, Anna
BLEDSOE, Mike
KLUCK, Brian
BRAVO, Javier
BLUESTEIN, Daniel
WHITE, Matt
LUONG, Nick
NOLAN, Ryan
VALENTINE, Elizabeth
FANG, Shiping
ZHU, Li
MARKOVICH, Robert
Priority Data
63/727,168
02.12.2024
US
63/740,586
31.12.2024
US
63/782,878
03.04.2025
US
Application details
| Total Number of Claims/PCT | * |
| Number of Independent Claims | * |
| Number of Priorities | * |
| Number of Multi-Dependent Claims | * |
| Number of Drawings | * |
| Pages for Publication | * |
| Number of Pages with Drawings | * |
| Pages of Specification | * |
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| Number of Office Actions | * |
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International Searching Authority |
EPO
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| Recordal of a Change of the Applicant's Name/Address |
Change of Applicant's Name and Address
* |
| Type of Assignment |
The Standard Agent's Assignment
* |
| Applicant's Legal Status |
Legal Entity
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| * | |
| * | |
| * | |
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| Entry into National Phase under |
Chapter I
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| Patent Delivery |
Send the Letters Patent by Courier
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| Translation |
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* The data is based on automatic recognition. Please verify and amend if necessary.
** IP-Coster compiles data from publicly available sources. If this data includes your personal information, you can contact us to request its removal.
Quotation for National Phase entry
| Country | Stages | Total | |
|---|---|---|---|
| China | Filing, Examination, Granting | 7989 | |
| EPO | Filing, Examination, Granting | 219753 | |
| Japan | Filing, Examination, Granting | 5398 | |
| South Korea | Filing, Examination, Granting | 12893 | |
| USA | Filing, Examination, Granting | 46240 |
Total:
292,273
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Abstract[English]
A method for producing a hyaluronidase polypeptide may include: a) introducing a nucleic acid molecule operably linked to a promotor into a eukaryotic cell, the nucleic acid molecule encoding a hyaluronidase polypeptide and including a stop codon; (b) culturing the cells in a growth medium having copper sulfate, L-glutamine, and L-cysteine sulfate under conditions whereby an encoded hyaluronidase polypeptide is produced by expression of the introduced nucleic acid molecule and secreted by the cell, the growth medium being devoid of sodium butyrate and insulin; and (c) recovering the expressed polypeptide.[French]
Un procédé de production d'un polypeptide hyaluronidase peut comprendre : a) l'introduction d'une molécule d'acide nucléique fonctionnellement liée à un promoteur dans une cellule eucaryote, la molécule d'acide nucléique codant pour un polypeptide hyaluronidase et comprenant un codon d'arrêt ; (b) cultiver les cellules dans un milieu de croissance ayant du sulfate de cuivre, de la L-glutamine et du sulfate de L-cystéine dans des conditions dans lesquelles un polypeptide d'hyaluronidase codé est produit par l'expression de la molécule d'acide nucléique introduite et sécrété par la cellule, le milieu de croissance étant dépourvu de butyrate de sodium et d'insuline ; et (c) récupérer le polypeptide exprimé.