WO2026110108 - METHODS OF DETECTING HOST CELL PROTEINS
National phase entry is expected:
Publication Number
WO/2026/110108
Publication Date
28.05.2026
International Application No.
PCT/IB2025/061973
International Filing Date
21.11.2025
Title **
[English]
METHODS OF DETECTING HOST CELL PROTEINS
[French]
PROCÉDÉS DE DÉTECTION DE PROTÉINES DE CELLULES HÔTES
Applicants **
SUN PHARMACEUTICAL INDUSTRIES LIMITED
Inventors
MODY, Rustom
NAGE, Nitin
LAYEK, Sourav
Priority Data
202421090896
22.11.2024
IN
Application details
| Total Number of Claims/PCT | * |
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International Searching Authority |
EPO
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| Recordal of a Change of the Applicant's Name/Address |
Change of Applicant's Name and Address
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| Type of Assignment |
The Standard Agent's Assignment
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| Applicant's Legal Status |
Legal Entity
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| Entry into National Phase under |
Chapter I
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| Patent Delivery |
Send the Letters Patent by Courier
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| Translation |
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* The data is based on automatic recognition. Please verify and amend if necessary.
** IP-Coster compiles data from publicly available sources. If this data includes your personal information, you can contact us to request its removal.
Quotation for National Phase entry
| Country | Stages | Total | |
|---|---|---|---|
| China | Filing, Examination, Granting | 2401 | |
| EPO | Filing, Examination, Granting | 14806 | |
| Japan | Filing, Examination, Granting | 2578 | |
| South Korea | Filing, Examination, Granting | 2853 | |
| USA | Filing, Examination, Granting | 6340 |
Total:
28,978
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Abstract[English]
The disclosure relates to methods of detecting Host Cell Proteins (HCPs) in biopharmaceutical samples containing a drug product. More specifically, the disclosure relates to methods of assaying HCPs in biopharmaceutical samples using enzymatic digestion protocols, liquid chromatography (LC) gradients, immunoaffinity capture protocols, and High-Resolution Mass Spectrometry (HRMS) to enhance the recovery, detection, and profiling of HCPs, which can impact the efficacy, shelf-life, and therapeutic response of drug products.[French]
La présente divulgation concerne des procédés de détection de protéines de cellules hôtes (HCP) dans des échantillons biopharmaceutiques contenant un produit médicamenteux. Plus spécifiquement, l'invention concerne des procédés de dosage de HCP dans des échantillons biopharmaceutiques à l'aide de protocoles de digestion enzymatique, de gradients de chromatographie en phase liquide (LC), de protocoles de capture par immunoaffinité, et de spectrométrie de masse à haute résolution (HRMS) pour améliorer la récupération, la détection et le profilage de HCP, qui peuvent impacter l'efficacité, la durée de conservation et la réponse thérapeutique de produits médicamenteux.