WO2026105091 - COMPOSITIONS AND METHODS TO MODULATE TRANSPOSABLE ELEMENTS GOVERNING CELL-STATE TRANSITIONS
National phase entry is expected:
Publication Number
WO/2026/105091
Publication Date
21.05.2026
International Application No.
PCT/IB2025/061762
International Filing Date
18.11.2025
Title **
[English]
COMPOSITIONS AND METHODS TO MODULATE TRANSPOSABLE ELEMENTS GOVERNING CELL-STATE TRANSITIONS
[French]
COMPOSITIONS ET MÉTHODES POUR MODULER DES ÉLÉMENTS TRANSPOSABLES RÉGISSANT DES TRANSITIONS D'ÉTATS CELLULAIRES
Applicants **
HAYA THERAPEUTICS SA
Inventors
IOURANOVA, Alexandra
BLESSING, Daniel Roman
OUNZAIN, Samir
MINA, Marco
DREOS, René
CRUZ DÁVALOS, Diana Ivette
MICHELETTI, Rudi
Priority Data
63/721,897
18.11.2024
US
Application details
| Total Number of Claims/PCT | * |
| Number of Independent Claims | * |
| Number of Priorities | * |
| Number of Multi-Dependent Claims | * |
| Number of Drawings | * |
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| Number of Pages with Drawings | * |
| Pages of Specification | * |
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| Number of Office Actions | * |
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International Searching Authority |
EPO
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| Recordal of a Change of the Applicant's Name/Address |
Change of Applicant's Name and Address
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| Type of Assignment |
The Standard Agent's Assignment
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| Applicant's Legal Status |
Legal Entity
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| * | |
| * | |
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| Entry into National Phase under |
Chapter I
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| Patent Delivery |
Send the Letters Patent by Courier
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| Translation |
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* The data is based on automatic recognition. Please verify and amend if necessary.
** IP-Coster compiles data from publicly available sources. If this data includes your personal information, you can contact us to request its removal.
Quotation for National Phase entry
| Country | Stages | Total | |
|---|---|---|---|
| China | Filing, Examination, Granting | 5102 | |
| EPO | Filing, Examination, Granting | 28282 | |
| Japan | Filing, Examination, Granting | 2842 | |
| South Korea | Filing, Examination, Granting | 3420 | |
| USA | Filing, Examination, Granting | 12190 |
Total:
51,836
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Abstract[English]
Disclosed herein are modulators of a transposable element or a transposable element transcript, wherein the modulators induce or facilitate a cell state transition or change. Further provided herein are synthetic polynucleic acids comprising a nucleic acid sequence of a transposable element or a portion thereof, wherein the synthetic polynucleic acids induce or facilitate cell state transitions or changes. Further provided herein are methods of preventing, alleviating, or treating pulmonary fibrosis in a subject in need thereof. Further provided herein are methods of cellular reprograming and reversing aging in a pulmonary tissue. Further provided herein are methods of diagnosing or prognosing pulmonary fibrosis.[French]
L'invention concerne des modulateurs d'un élément transposable ou d'une transcription d'élément transposable, les modulateurs induisant ou permettant une transition ou un changement d'états cellulaires. L'invention concerne également des acides polynucléiques synthétiques comprenant une séquence d'acide nucléique d'un élément transposable ou une partie de celui-ci, les acides polynucléiques synthétiques induisant ou permettant des transitions ou des changements d'états cellulaires. L'invention concerne en outre des méthodes de prévention, d'atténuation ou de traitement de la fibrose pulmonaire chez un sujet en ayant besoin. L'invention concerne de plus des méthodes de reprogrammation cellulaire et d'inversion du vieillissement d'un tissu pulmonaire. L'invention concerne enfin des méthodes de diagnostic ou de pronostic de la fibrose pulmonaire.