WO2026078659 - COMBINATION OF TRISPECIFIC ANTIBODY TARGETING BCMA, GPRC5D AND CD3, AND AN ANTI-CD38 ANTIBODY FOR THE TREATMENT OF MULTIPLE MYELOMA
National phase entry is expected:
Publication Number
WO/2026/078659
Publication Date
16.04.2026
International Application No.
PCT/IB2025/060306
International Filing Date
10.10.2025
Title **
[English]
COMBINATION OF TRISPECIFIC ANTIBODY TARGETING BCMA, GPRC5D AND CD3, AND AN ANTI-CD38 ANTIBODY FOR THE TREATMENT OF MULTIPLE MYELOMA
[French]
COMBINAISON D'UN ANTICORPS TRISPÉCIFIQUE CIBLANT BCMA, GPRC5D ET CD3 ET D'UN ANTICORPS ANTI-CD38 POUR LE TRAITEMENT DU MYÉLOME MULTIPLE
Applicants **
JANSSEN BIOTECH, INC.
Inventors
LEE, Sangmin
DASKALAKIS, Nikki
HILDER, Brandi Whitley
NGUYEN, Ashley
PASTORE, Alessandro
Priority Data
63/706,347
11.10.2024
US
63/738,277
23.12.2024
US
63/809,555
21.05.2025
US
Application details
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International Searching Authority |
EPO
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| Recordal of a Change of the Applicant's Name/Address |
Change of Applicant's Name and Address
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| Type of Assignment |
The Standard Agent's Assignment
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| Applicant's Legal Status |
Legal Entity
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| Entry into National Phase under |
Chapter I
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| Patent Delivery |
Send the Letters Patent by Courier
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| Translation |
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* The data is based on automatic recognition. Please verify and amend if necessary.
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Quotation for National Phase entry
| Country | Stages | Total | |
|---|---|---|---|
| China | Filing, Examination, Granting | 8626 | |
| EPO | Filing, Examination, Granting | 201550 | |
| Japan | Filing, Examination, Granting | 5405 | |
| South Korea | Filing, Examination, Granting | 12377 | |
| USA | Filing, Examination, Granting | 47390 |
Total:
275,348
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Abstract[English]
Embodiments disclosed herein relate to methods of treating multiple myeloma in a subject in need thereof, comprising administering a therapeutically effective amount of BCMA x GPRC5D x CD3 trispecific antibody or trispecific binding fragment thereof and an anti-CD38 antibody, to the subject to the subject to treat the multiple myeloma.[French]
Des modes de réalisation de la présente invention concernent des méthodes de traitement du myélome multiple chez un sujet en ayant besoin, consistant à administrer au sujet une quantité thérapeutiquement efficace d'un anticorps trispécifique ciblant BCMA, GPRC5D et CD3, ou d'un fragment de liaison trispécifique de celui-ci, et d'un anticorps anti-CD38 pour traiter le myélome multiple.