WO2026062521 - METHODS AND COMPOUNDS FOR PROMOTING SURVIVAL OF PHOTORECEPTORS

National phase entry is expected:
Publication Number WO/2026/062521
Publication Date 26.03.2026
International Application No. PCT/IB2025/059319
International Filing Date 17.09.2025
Title **
[English] METHODS AND COMPOUNDS FOR PROMOTING SURVIVAL OF PHOTORECEPTORS
[French] PROCÉDÉS ET COMPOSÉS POUR FAVORISER LA SURVIE DE PHOTORÉCEPTEURS
Applicants **
INSTITUTE OF MOLECULAR AND CLINICAL OPHTHALMOLOGY BASEL (IOB)
Inventors
SPIRIG, Stefan Erich
ROSKA, Botond Miklós
Priority Data
63/696,182   18.09.2024   US
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Quotation for National Phase entry

Country StagesTotal
China Filing, Examination, Granting5754
EPO Filing, Examination, Granting66523
Japan Filing, Examination, Granting4091
South Korea Filing, Examination, Granting5679
USA Filing, Examination, Granting20540
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Total: 102,587
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Abstract[English] The disclosure relates to methods of treating photoreceptor disease and/or inhibiting degeneration or death of photoreceptors. The methods comprise administering to a subject in need thereof a therapeutically effective amount of an inhibitor of mitogen-activated protein kinase 11 (MAPK11), an inhibitor of casein kinase 1 (CK1), or combinations thereof. This disclosure also relates to certain inhibitors of MAPK11 or CK1 and to pharmaceutical compositions that contain such inhibitors.[French] La divulgation concerne des méthodes de traitement d'une maladie de photorécepteurs et/ou d'inhibition de la dégénérescence ou de la mort de photorécepteurs. Les procédés consistent à administrer à un sujet qui en a besoin une quantité thérapeutiquement efficace d'un inhibiteur de protéine kinase 11 activée par mitogène (MAPK11), d'un inhibiteur de caséine kinase 1 (CK1), ou de combinaisons de ceux-ci. La présente divulgation concerne également certains inhibiteurs de MAPK11 ou CK1 et des compositions pharmaceutiques qui contiennent de tels inhibiteurs.

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