WO2026053114 - FUSED BICYCLIC HETEROCYCLYL COMPOUNDS AND THEIR DERIVATIVES AS P300 SELECTIVE DEGRADERS
National phase entry is expected:
Publication Number
WO/2026/053114
Publication Date
12.03.2026
International Application No.
PCT/IB2025/058852
International Filing Date
03.09.2025
Title **
[English]
FUSED BICYCLIC HETEROCYCLYL COMPOUNDS AND THEIR DERIVATIVES AS P300 SELECTIVE DEGRADERS
[French]
COMPOSÉS HÉTÉROCYCLYLE BICYCLIQUES FUSIONNÉS ET LEURS DÉRIVÉS EN TANT QU'AGENTS DE DÉGRADATION SÉLECTIFS DE P300
Applicants **
AURIGENE ONCOLOGY LIMITED
Inventors
ABBINENI, Chandrasekhar
TALLURI, Krishna Chaitanya
SAMAJDAR, Susanta
Priority Data
202441066883
04.09.2024
IN
Application details
| Total Number of Claims/PCT | * |
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International Searching Authority |
EPO
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| Recordal of a Change of the Applicant's Name/Address |
Change of Applicant's Name and Address
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| Type of Assignment |
The Standard Agent's Assignment
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| Applicant's Legal Status |
Legal Entity
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| Entry into National Phase under |
Chapter I
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| Patent Delivery |
Send the Letters Patent by Courier
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| Translation |
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* The data is based on automatic recognition. Please verify and amend if necessary.
** IP-Coster compiles data from publicly available sources. If this data includes your personal information, you can contact us to request its removal.
Quotation for National Phase entry
| Country | Stages | Total | |
|---|---|---|---|
| China | Filing, Examination, Granting | 2854 | |
| EPO | Filing, Examination, Granting | 17332 | |
| Japan | Filing, Examination, Granting | 2640 | |
| South Korea | Filing, Examination, Granting | 2976 | |
| USA | Filing, Examination, Granting | 10340 |
Total:
36,142
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Abstract[English]
The present disclosure provides fused bicyclic heterocyclyl compounds of formula (I) and their derivatives, that are therapeutically useful as p300 degraders. These compounds are useful in the treatment and/or prevention of diseases and/or disorders responsive to the p300 protein degradation. Compounds of the present disclosure are especially useful for treating cancer, autoimmune, inflammatory and neurodegenerative diseases and disorders. The present disclosure also provides processes for preparation of the compounds and pharmaceutical formulations comprising at least one of the compounds of formula (I) or a pharmaceutically acceptable salt or a stereoisomer thereof.[French]
La présente divulgation concerne des composés hétérocyclyle bicycliques fusionnés de formule (I) et leurs dérivés, qui sont thérapeutiquement utiles en tant qu'agents de dégradation de p300. Ces composés sont utiles dans le traitement et/ou la prévention de maladies et/ou de troubles sensibles à la dégradation de la protéine p300. Les composés de la présente divulgation sont particulièrement utiles pour le traitement du cancer, de maladies et de troubles auto-immuns, inflammatoires et neurodégénératifs. La présente divulgation concerne également des procédés de préparation des composés et des formulations pharmaceutiques comprenant au moins l'un des composés de formule (I) ou un sel pharmaceutiquement acceptable ou un stéréoisomère de ceux-ci.