WO2026047627 - NANOSEQUENCING DEVICE BASED ON REDOX-LABELING AND A ROTATIONALLY SYMMETRIC ELECTRODE ARRANGEMENT AROUND A NANOPORE
National phase entry is expected:
Publication Number
WO/2026/047627
Publication Date
05.03.2026
International Application No.
PCT/IB2025/058754
International Filing Date
29.08.2025
Title **
[English]
NANOSEQUENCING DEVICE BASED ON REDOX-LABELING AND A ROTATIONALLY SYMMETRIC ELECTRODE ARRANGEMENT AROUND A NANOPORE
[French]
DISPOSITIF DE NANOSÉQUENÇAGE BASÉ SUR LE MARQUAGE REDOX ET AGENCEMENT D'ÉLECTRODES À SYMÉTRIE DE ROTATION AUTOUR D'UN NANOPORE
Applicants **
ROBERT BOSCH GMBH
Inventors
LAERMER, Franz
HUEBNER, Martina
FOMINA, Nadezda
JOHNSON, Christopher
SHIK, Shin Young
LANG, Christoph
Priority Data
18/820,896
30.08.2024
US
Application details
| Total Number of Claims/PCT | * |
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International Searching Authority |
EPO
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| Recordal of a Change of the Applicant's Name/Address |
Change of Applicant's Name and Address
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| Type of Assignment |
The Standard Agent's Assignment
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| Applicant's Legal Status |
Legal Entity
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| * | |
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| Entry into National Phase under |
Chapter I
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| Patent Delivery |
Send the Letters Patent by Courier
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| Translation |
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* The data is based on automatic recognition. Please verify and amend if necessary.
** IP-Coster compiles data from publicly available sources. If this data includes your personal information, you can contact us to request its removal.
Quotation for National Phase entry
| Country | Stages | Total | |
|---|---|---|---|
| China | Filing, Examination, Granting | 2253 | |
| EPO | Filing, Examination, Granting | 12202 | |
| Japan | Filing, Examination, Granting | 2420 | |
| South Korea | Filing, Examination, Granting | 2535 | |
| USA | Filing, Examination, Granting | 5340 |
Total:
24,750
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Abstract[English]
A system for sequencing a polynucleotide strand including a device with a layer stack on a silicon wafer. The layer stack may include a first electrode and a second electrode separated by a dielectric insulating layer and a nanohole drilled through the layer stack so that the first and second electrodes are rotationally arranged around the nanohole. A polynucleotide strand with at least one nucleotide and at least one electroactive label may be pulled through the nanohole. The system may additionally include a controller that may apply an electrical signal to the first and second electrodes, measure a current (I) as a function of an applied potential (V) when an electroactive label is guided through the nanohole of the device, and adjust an electrical voltage to pull the polynucleotide strand through the nanohole at a predetermined speed.[French]
L'invention concerne un système de séquençage d'un brin polynucléotidique comprenant un dispositif avec un empilement de couches sur une tranche de silicium. L'empilement de couches peut comprendre une première électrode et une seconde électrode séparées par une couche isolante diélectrique et un nano-trou percé à travers l'empilement de couches de telle sorte que les première et seconde électrodes soient disposées à symétrie de rotation autour du nano-trou. Un brin polynucléotidique ayant au moins un nucléotide et au moins un marqueur électroactif peut être tiré à travers le nano-trou. Le système peut en outre comprendre un dispositif de commande qui peut appliquer un signal électrique aux première et seconde électrodes, mesurer un courant (I) en fonction d'un potentiel appliqué (V) lorsqu'un marqueur électroactif est guidé à travers le nano-trou du dispositif, et ajuster une tension électrique pour tirer le brin polynucléotidique à travers le nano-trou à une vitesse prédéterminée.