WO2025229549 - NOVEL HETEROCYCLIC COMPOUNDS AS INHIBITORS OF PARG

National phase entry is expected:
Publication Number WO/2025/229549
Publication Date 06.11.2025
International Application No. PCT/IB2025/054486
International Filing Date 30.04.2025
Title **
[English] NOVEL HETEROCYCLIC COMPOUNDS AS INHIBITORS OF PARG
[French] NOUVEAUX COMPOSÉS HÉTÉROCYCLIQUES UTILISÉS EN TANT QU'INHIBITEURS DE PARG
Applicants **
SATYARX PHARMA INNOVATIONS PVT LTD
Inventors
CHAVALI, Satyanarayana Murthy
PUJALA, Brahmam
Priority Data
202341082368   30.04.2024   IN
202441062128   16.08.2024   IN
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Quotation for National Phase entry

Country StagesTotal
China Filing, Examination, Granting5438
EPO Filing, Examination, Granting77583
Japan Filing, Examination, Granting4317
South Korea Filing, Examination, Granting6616
USA Filing, Examination, Granting66890
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Total: 160,844
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Abstract[English] The present invention relates to novel heterocyclic compounds of formula (I) as inhibitors of PARG, their pharmaceutically acceptable salts, stereoisomers, solvates, polymorphs, tautomers, atropisomers, optical and geometric isomers, prodrugs, deuterated including other possible isotopes, combinations and use thereof in treating cancer. Formula (I) The present invention also relates to a process for the preparation of novel heterocyclic compounds of Formula (I), pharmaceutical compositions comprising them, and their use in the treatment of cancer.[French] La présente invention concerne de nouveaux composés hétérocycliques de formule (I) en tant qu'inhibiteurs de PARG, leurs sels, stéréoisomères, solvates, polymorphes, tautomères, atropisomères, isomères optiques et géométriques, promédicaments, composés deutérés comprenant d'autres isotopes possibles, des combinaisons et leur utilisation dans le traitement du cancer. La présente invention concerne également un procédé de préparation de nouveaux composés hétérocycliques de formule (I), des compositions pharmaceutiques les comprenant, et leur utilisation dans le traitement du cancer.

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