WO2025224715 - METHODS FOR IMPROVING PRECISE GENOME MODIFICATION AND REDUCING UNWANTED MUTATIONS BY CRISPR-CAS EDITING
National phase entry is expected:
Publication Number
WO/2025/224715
Publication Date
30.10.2025
International Application No.
PCT/IB2025/054391
International Filing Date
28.04.2025
Title **
[English]
METHODS FOR IMPROVING PRECISE GENOME MODIFICATION AND REDUCING UNWANTED MUTATIONS BY CRISPR-CAS EDITING
[French]
PROCÉDÉS D'AMÉLIORATION DE MODIFICATION PRÉCISE DU GÉNOME ET DE RÉDUCTION DE MUTATIONS INDÉSIRABLES PAR ÉDITION DE CRISPR-CAS
Applicants **
KING ABDULLAH UNIVERISTY OF SCIENCE AND TECHNOLOGY
Inventors
LI, Mo
YUAN, Baolei
Priority Data
63/639,573
26.04.2024
US
63/723,422
21.11.2024
US
Application details
| Total Number of Claims/PCT | * |
| Number of Independent Claims | * |
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International Searching Authority |
EPO
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| Recordal of a Change of the Applicant's Name/Address |
Change of Applicant's Name and Address
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| Type of Assignment |
The Standard Agent's Assignment
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| Applicant's Legal Status |
Legal Entity
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| * | |
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| Entry into National Phase under |
Chapter I
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| Patent Delivery |
Send the Letters Patent by Courier
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| Translation |
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* The data is based on automatic recognition. Please verify and amend if necessary.
** IP-Coster compiles data from publicly available sources. If this data includes your personal information, you can contact us to request its removal.
Quotation for National Phase entry
| Country | Stages | Total | |
|---|---|---|---|
| China | Filing, Examination, Granting | 2662 | |
| EPO | Filing, Examination, Granting | 11975 | |
| Japan | Filing, Examination, Granting | 2285 | |
| South Korea | Filing, Examination, Granting | 2336 | |
| USA | Filing, Examination, Granting | 4740 |
Total:
23,998
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Abstract[English]
Compositions and methods for increasing the homology directed repair (HDR) efficiency following CRISPER/CAS mediated gene editing are disclosed, include (A) Agents that reduce PoLQ level/activity in a cell; (B) agents that increase RPA levels/activity in a cell and (C) fluorophore-modified nucleic acids used in gene editing.[French]
Des compositions et des procédés pour augmenter l'efficacité de réparation dirigée par l'homologie (HDR) après l'édition génique médiée par CRISPER/CAS sont divulgués, comprenant (A) des agents qui réduisent le niveau/l'activité de PoLQ dans une cellule ; (B) des agents qui augmentent les niveaux/l'activité de RPA dans une cellule et (C) des acides nucléiques modifiés par fluorophore utilisés dans l'édition génique.