WO2025210584 - RECONSTITUTED HIGH DENSITY LIPOPROTEIN TREATMENT OF MYOCARDIAL INFARCTION

National phase entry is expected:
Publication Number WO/2025/210584
Publication Date 09.10.2025
International Application No. PCT/IB2025/053584
International Filing Date 04.04.2025
Title **
[English] RECONSTITUTED HIGH DENSITY LIPOPROTEIN TREATMENT OF MYOCARDIAL INFARCTION
[French] TRAITEMENT DE L'INFARCTUS DU MYOCARDE À L'AIDE D'UNE LIPOPROTÉINE DE HAUTE DENSITÉ RECONSTITUÉE
Applicants **
CSL INNOVATION PTY LTD
Inventors
DANIELLE, Duffy
GIBSON, Charles Michael
KINGWELL, Bronwyn
Priority Data
63/574,755   04.04.2024   US
63/723,388   21.11.2024   US
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Quotation for National Phase entry

Country StagesTotal
China Filing, Examination, Granting3949
EPO Filing, Examination, Granting32266
Japan Filing, Examination, Granting3229
South Korea Filing, Examination, Granting4329
USA Filing, Examination, Granting12790
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Total: 56,563
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Abstract[English] Agents that enhance cholesterol efflux from macrophages within atherosclerotic plaques, such as reconstituted HDL formulations, and methods of treatment comprising same and uses thereof are provided for treating patients after an acute myocardial infarction (MI) event. The treatments of MI patients with the agents reduce the risk of one or more or all of CV death, a subsequent MI, and stent thrombosis-related MI (type 4b MI) in a human patient after an acute myocardial infarction (MI) event.[French] L'invention concerne des agents qui améliorent l'efflux de cholestérol à partir de macrophages dans des plaques athéroscléreuses, telles que des formulations de HDL reconstituée, et des méthodes de traitement comprenant ceux-ci et leurs utilisations pour traiter des patients après un événement d'infarctus du myocarde aigu (IM). Les traitements de patients atteints d'IM avec les agents réduisent l'un ou plusieurs ou l'ensemble des risques de mort cardiovasculaire, d'IM ultérieur et d'IM lié à une thrombose de stent (IM de type 4b) chez un patient humain après un événement d'infarctus du myocarde aigu (MI).

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