WO2025210581 - A NOVEL PROCESS FOR THE PREPARATION OF (6R)-6-(2-(N-(4-(2-(ETHYLAMINO) ETHYL) BENZYL)-N-ETHYLAMINO)-4-METHOXYPHENYL)-5,6,7,8-TETRAHYDRONAPHTHALEN-2-OL DIHYDROCHLORIDE AND IT'S INTEMEDIATES
National phase entry is expected:
Publication Number
WO/2025/210581
Publication Date
09.10.2025
International Application No.
PCT/IB2025/053575
International Filing Date
04.04.2025
Title **
[English]
A NOVEL PROCESS FOR THE PREPARATION OF (6R)-6-(2-(N-(4-(2-(ETHYLAMINO) ETHYL) BENZYL)-N-ETHYLAMINO)-4-METHOXYPHENYL)-5,6,7,8-TETRAHYDRONAPHTHALEN-2-OL DIHYDROCHLORIDE AND IT'S INTEMEDIATES
[French]
NOUVEAU PROCÉDÉ DE PRÉPARATION DE DICHLORHYDRATE DE (6R)-6-(2-(N-(4-(2-(ÉTHYLAMINO)ÉTHYL)BENZYL)-N-ÉTHYLAMINO)-4-MÉTHOXYPHÉNYL)-5,6,7,8-TÉTRAHYDRONAPHTALÉN-2-OL ET SES INTERMÉDIAIRES
Applicants **
BIOPHORE INDIA PHARMACEUTICALS PVT. LTD
Inventors
PULLAGURLA, Manik Reddy
PITTA, Bhaskar Reddy
RANGISETTY, Jagadeesh Babu
Priority Data
202441027906
04.04.2024
IN
Application details
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International Searching Authority |
IP India
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| Recordal of a Change of the Applicant's Name/Address |
Change of Applicant's Name and Address
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| Type of Assignment |
The Standard Agent's Assignment
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| Applicant's Legal Status |
Legal Entity
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| Entry into National Phase under |
Chapter I
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| Patent Delivery |
Send the Letters Patent by Courier
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| Translation |
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Quotation for National Phase entry
| Country | Stages | Total | |
|---|---|---|---|
| China | Filing, Examination, Granting | 2099 | |
| EPO | Filing, Examination, Granting | 12141 | |
| Japan | Filing, Examination, Granting | 2016 | |
| South Korea | Filing, Examination, Granting | 1794 | |
| USA | Filing, Examination, Granting | 7740 |
Total:
25,790
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Abstract[English]
The present invention relates to a process for the preparation of (6R)-6-(2-(N-(4-(2- (ethylamino)ethyl)benzyl)-N-ethylamino)-4-methoxyphenyl)-5,6,7,8-tetrahydro nap- hthalen-2-ol dihydrochloride (1) and its novel intermediates thereof. Elacestrant dihydrochloride (1) The present invention further relates to a process for the preparation of intermediates of formula (3), formula (4), formula (4a), formula (5), formula (5a), formula (6), formula (6a), formula (7), formula (7a), formula (9) and formula (10). with enantiomeric excess greater than 50%.[French]
La présente invention concerne un procédé de préparation de dichlorhydrate de (6R)-6-(2-(N-(4-(2-(éthylamino)éthyl)benzyl)-N-éthylamino)-4-méthoxyphényl)-5,6,7,8-tétrahydronaphthalèn-2-ol (1) et de nouveaux intermédiaires de celui-ci. La présente invention concerne en outre un procédé de préparation d'intermédiaires de formule (3), de formule (4), de formule (4a), de formule (5), de formule (5a), de formule (6), de formule (6a), de formule (7), de formule (7a), de formule (9) et de formule (10) avec un excès énantiomérique supérieur à 50%.