WO2025169146 - CD40 ANTAGONIST OR CD154 ANTAGONIST FOR USE IN MITIGATING IMMUNE RESPONSES IN PROTEIN AND GENE THERAPIES

National phase entry is expected:
Publication Number WO/2025/169146
Publication Date 14.08.2025
International Application No. PCT/IB2025/051326
International Filing Date 07.02.2025
Title **
[English] CD40 ANTAGONIST OR CD154 ANTAGONIST FOR USE IN MITIGATING IMMUNE RESPONSES IN PROTEIN AND GENE THERAPIES
[French] ANTAGONISTE DE CD40 OU ANTAGONISTE DE CD154 DESTINÉ À ÊTRE UTILISÉ DANS L'ATTÉNUATION DE RÉPONSES IMMUNITAIRES DANS DES THÉRAPIES PROTÉIQUES ET GÉNIQUES
Applicants **
KINIKSA PHARMACEUTICALS, GMBH
Inventors
PAOLINI, John F.
TESSARI, Eben
ATAMAS, Sergei
Priority Data
63/551,977   09.02.2024   US
Application details
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Quotation for National Phase entry

Country StagesTotal
China Filing, Examination, Granting2906
EPO Filing, Examination, Granting20952
Japan Filing, Examination, Granting2923
South Korea Filing, Examination, Granting3370
USA Filing, Examination, Granting8340
MasterCard Visa
Total: 38,491
Abstract[English] Featured are the use of pharmaceutical compositions containing a CD40 antagonist or a CD154 antagonist for the treatment, reduction, and/or inhibition of an immune response, such as an anti-drug antibody response, following, e.g., protein replacement therapy or gene therapy.[French] L'invention concerne l'utilisation de compositions pharmaceutiques contenant un antagoniste de CD40 ou un antagoniste de CD154 pour le traitement, la réduction et/ou l'inhibition d'une réponse immunitaire, telle qu'une réponse d'anticorps anti-médicament, après, par exemple, une thérapie de remplacement de protéines ou une thérapie génique.

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