WO2025154000 - A PROCESS FOR PRODUCTION OF ALPHA-STRUCTURAL ISOMER OF (±)-CIS-3-(2'-BENZIMIDAZOLYL)-1,2,2-TRIMETHYLCYCLOPENTANECARBONIC ACID AND ITS SALTS
National phase entry is expected:
Publication Number
WO/2025/154000
Publication Date
24.07.2025
International Application No.
PCT/IB2025/050496
International Filing Date
17.01.2025
Title **
[English]
A PROCESS FOR PRODUCTION OF ALPHA-STRUCTURAL ISOMER OF (±)-CIS-3-(2'-BENZIMIDAZOLYL)-1,2,2-TRIMETHYLCYCLOPENTANECARBONIC ACID AND ITS SALTS
[French]
PROCÉDÉ DE PRODUCTION D'ISOMÈRE STRUCTURAL ALPHA D'ACIDE (±)-CIS-3-(2'-BENZIMIDAZOLYL)-1,2,2-TRIMÉTHYLCYCLOPENTANECARBONIQUE ET DE SES SELS
Applicants **
"MEDICAL CENTER M.T.K." LLC
Inventors
GUMENIUK, Mykola
Priority Data
a202400284
17.01.2024
UA
u202400304
18.01.2024
UA
u202400305
18.01.2024
UA
Application details
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International Searching Authority |
EPO
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| Recordal of a Change of the Applicant's Name/Address |
Change of Applicant's Name and Address
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| Type of Assignment |
The Standard Agent's Assignment
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| Applicant's Legal Status |
Legal Entity
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| Entry into National Phase under |
Chapter I
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| Patent Delivery |
Send the Letters Patent by Courier
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| Translation |
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Quotation for National Phase entry
| Country | Stages | Total | |
|---|---|---|---|
| China | Filing, Examination, Granting | 2237 | |
| EPO | Filing, Examination, Granting | 9752 | |
| Japan | Filing, Examination, Granting | 2265 | |
| South Korea | Filing, Examination, Granting | 2286 | |
| USA | Filing, Examination, Granting | 4740 |
Total:
21,280
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Abstract[English]
This disclosure relates to the chemical and pharmaceutical field, namely processes for production of alpha-structural isomer of (±)-cis-3-(2'-benzimidazolyl)-1,2,2- trimethylcyclopentanecarboxylic acid and its salts. The process according to the disclosure comprises the steps such as reacting o- phenylenediamine and (±)-camphoric anhydride compounds, isolating and purifying the alpha-structural isomer of (±)-cis-3-(2'-benzimidazolyl)-1,2,2- trimethylcyclopentanecarboxylic acid and, if applicable, the step of producing and purifying the salt. The technical contribution resides in the improvement of the process for production of the alpha-structural isomer of (±)-cis-3-(2'-benzimidazolyl)-1,2,2- trimethylcyclopentanecarboxylic acid and its salts, that comprises fewer steps, lower use of the organic solvents, and production of the final product with high purity.[French]
La présente divulgation relève du domaine chimique et pharmaceutique, à savoir des procédés de production d'isomère structural alpha d'acide (±)-cis-3-(2'-benzimidazolyl)-1,2,2-triméthylcyclopentanecarboxylique et de ses sels. Le procédé selon la divulgation comprend des étapes telles que la réaction d'o-phénylènediamine et de composés d'anhydride (±)-camphorique, l'isolement et la purification de l'isomère structural alpha de l'acide (±)-cis-3-(2'-benzimidazolyl)-1,2,2-triméthylcyclopentanecarboxylique et, le cas échéant, une étape de production et de purification du sel. La contribution technique réside dans l'amélioration du procédé de production de l'isomère structural alpha de l'acide (±)-cis-3-(2'-benzimidazolyl)-1,2,2-triméthylcyclopentanecarboxylique et de ses sels, qui comprend moins d'étapes, une faible utilisation des solvants organiques, et la production du produit final avec une pureté élevée.