WO2025253181 - APPARATUS AND METHODS FOR MONITORING A POLYPEPTIDE TYPE CONCENTRATION IN A MULTI-STEP BIOLOGIC PRODUCTION PROCESS
National phase entry is expected:
Publication Number
WO/2025/253181
Publication Date
11.12.2025
International Application No.
PCT/IB2025/000296
International Filing Date
06.06.2025
Title **
[English]
APPARATUS AND METHODS FOR MONITORING A POLYPEPTIDE TYPE CONCENTRATION IN A MULTI-STEP BIOLOGIC PRODUCTION PROCESS
[French]
APPAREIL ET PROCÉDÉS DE SURVEILLANCE DE CONCENTRATION DE TYPE DE POLYPEPTIDE DANS UN PROCESSUS DE PRODUCTION BIOLOGIQUE EN PLUSIEURS ÉTAPES
Applicants **
TAKEDA PHARMACEUTICAL COMPANY LIMITED
Inventors
MADLENER, Ruth
DOEL-PEREZ, Iago
SARAULLO, Matteo
TESCHNER, Wolfgang
STROHMER, Daniel
Priority Data
63/657,518
07.06.2024
US
63/747,181
20.01.2025
US
Application details
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| Number of Multi-Dependent Claims | * |
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International Searching Authority |
EPO
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| Recordal of a Change of the Applicant's Name/Address |
Change of Applicant's Name and Address
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| Type of Assignment |
The Standard Agent's Assignment
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| Applicant's Legal Status |
Legal Entity
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| * | |
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| Entry into National Phase under |
Chapter I
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| Patent Delivery |
Send the Letters Patent by Courier
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| Translation |
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Quotation for National Phase entry
| Country | Stages | Total | |
|---|---|---|---|
| China | Filing, Examination, Granting | 7474 | |
| EPO | Filing, Examination, Granting | 193481 | |
| Japan | Filing, Examination, Granting | 5257 | |
| South Korea | Filing, Examination, Granting | 11755 | |
| USA | Filing, Examination, Granting | 39640 |
Total:
257,607
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Abstract[English]
Methods for monitoring a polypeptide type concentration comprise obtaining a first signal from first measurements from a first substrate-based sensor exposed to a biologic sample. The first signal includes a resonance contribution for each first measurement, for each of a first plurality of polypeptide types, based on polypeptide type concentration in the sample and first substrate binding affinity for the polypeptide type. A second signal is obtained from second measurements from a second substrate-based sensor exposed to the sample. The second signal includes a resonance contribution for each second measurement, for each of a second plurality of polypeptide types, based on polypeptide type concentration in the sample and second substrate binding affinity for the polypeptide type. The first and second substrate binding affinity for a first polypeptide type in biologic sample differ. The first polypeptide type concentration is determined using the first and second signals.[French]
Des procédés de surveillance d'une concentration de type de polypeptide selon l'invention consistent à obtenir un premier signal à partir de premières mesures provenant d'un premier capteur à base de substrat exposé à un échantillon biologique. Le premier signal comprend une contribution de résonance pour chaque première mesure, pour chaque type d'une première pluralité de types de polypeptides, sur la base d'une concentration du type de polypeptide dans l'échantillon et d'une première affinité de liaison de substrat pour le type de polypeptide. Un second signal est obtenu à partir de secondes mesures effectuées par un second capteur à base de substrat exposé à l'échantillon. Le second signal comprend une contribution de résonance pour chaque seconde mesure, pour chaque type d'une seconde pluralité de types de polypeptides, sur la base d'une concentration de type de polypeptide dans l'échantillon et d'une seconde affinité de liaison de substrat pour le type de polypeptide. Les première et seconde affinités de liaison de substrat pour un premier type de polypeptide dans un échantillon biologique diffèrent. La concentration du premier type de polypeptide est déterminée à l'aide des premier et second signaux.