WO2025114853 - PHOTOSWITCHABLE COMPOUNDS MODULATING CADHERIN HOMODIMERIZATION
National phase entry is expected:
Publication Number
WO/2025/114853
Publication Date
05.06.2025
International Application No.
PCT/IB2024/061782
International Filing Date
25.11.2024
Title **
[English]
PHOTOSWITCHABLE COMPOUNDS MODULATING CADHERIN HOMODIMERIZATION
[French]
COMPOSÉS PHOTOCOMMUTABLES MODULANT L'HOMODIMÉRISATION DE LA CADHÉRINE
Applicants **
LATVIAN INSTITUTE OF ORGANIC SYNTHESIS
FUNDACIÓ INSTITUT DE BIOENGINYERIA DE CATALUNYA
INSTITUCIÓ CATALANA DE RECERCA I ESTUDIS AVANCATS
Inventors
CASTAGNA, Rossella
PARISINI, Emilio
KAUSER, Ambreen
GOROSTIZA, Pau
Priority Data
LVP2023000129
30.11.2023
LV
Application details
| Total Number of Claims/PCT | * |
| Number of Independent Claims | * |
| Number of Priorities | * |
| Number of Multi-Dependent Claims | * |
| Number of Drawings | * |
| Pages for Publication | * |
| Number of Pages with Drawings | * |
| Pages of Specification | * |
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| Number of Office Actions | * |
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International Searching Authority |
EPO
* |
| Recordal of a Change of the Applicant's Name/Address |
Change of Applicant's Name and Address
* |
| Type of Assignment |
The Standard Agent's Assignment
* |
| Applicant's Legal Status |
Legal Entity
* |
| * | |
| * | |
| * | |
| * | |
| * | |
| Entry into National Phase under |
Chapter I
* |
| Patent Delivery |
Send the Letters Patent by Courier
* |
| Translation |
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* The data is based on automatic recognition. Please verify and amend if necessary.
** IP-Coster compiles data from publicly available sources. If this data includes your personal information, you can contact us to request its removal.
Quotation for National Phase entry
| Country | Stages | Total | |
|---|---|---|---|
| China | Filing, Examination, Granting | 1874 | |
| EPO | Filing, Examination, Granting | 8154 | |
| Japan | Filing, Examination, Granting | 1829 | |
| South Korea | Filing, Examination, Granting | 1367 | |
| USA | Filing, Examination, Granting | 4740 |
Total:
17,964
The term for entry into the National Phase has expired. This quotation is for informational purposes only
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Abstract[English]
Invention relates to photoswitchable azobenzene-based compounds, particularly to azobenzene-based compounds that allows light-triggered modulation of the cell-cell adhesion family of proteins called cadherins and their use in the treatment of cancer and other diseases. We have discovered photoswitchable compounds that are active at < 100 μM concentration on BxPC-3 cells expressing E-cadherin and P-cadherin. These novel compounds can be used for manufacturing of various pharmaceutical compositions, wherein they are present together with one or more pharmaceutically acceptable diluents, carriers or excipients.[French]
L'invention concerne des composés photocommutables à base d'azobenzène, en particulier des composés à base d'azobenzène qui permettent une modulation déclenchée par la lumière de la famille d'adhérence cellule-cellule de protéines appelées cadhérines et leur utilisation dans le traitement du cancer et d'autres maladies. Nous avons découvert des composés photocommutables qui sont actifs à une concentration < 100 μΜ sur des cellules BxPC -3 exprimant l'E-cadhérine et la P-cadhérine. Ces nouveaux composés peuvent être utilisés pour la préparation de diverses compositions pharmaceutiques, dans lesquelles ils sont présents conjointement avec un ou plusieurs diluants, supports ou excipients pharmaceutiquement acceptables.