WO2025078984 - SUBSTITUTED TRICYCLIC COMPOUNDS AS KRAS DEGRADERS
National phase entry:
Publication Number
WO/2025/078984
Publication Date
17.04.2025
International Application No.
PCT/IB2024/059901
International Filing Date
10.10.2024
Title **
[English]
SUBSTITUTED TRICYCLIC COMPOUNDS AS KRAS DEGRADERS
[French]
COMPOSÉS TRICYCLIQUES SUBSTITUÉS UTILISÉS EN TANT QU'AGENTS DE DÉGRADATION DE KRAS
Applicants **
AURIGENE ONCOLOGY LIMITED
Inventors
CHIKKANNA, Dinesh
AELURI, Madhu
MUKHERJEE, Subhendu
TATYASAHEB GORE, Suraj
ABBINENI, Chandrasekhar
MAKKIKOPPA VITTALARAO, Ravindra
BASAK, Debajyoti
SAMAJDAR, Susanta
SIMONOVICH, Scott
GREEN, Evan
MURRAY, Jeremy
MISHRA, Nigam
CHEN, Jun
RAIKAR, Sandeep
SHERER, Brian
NGUYEN, Huy
FERREIRA, Andrew
MAUNG, Jack
COLE, David
KHRAKOVSKY, Dimitri
BUI, Minna
Priority Data
202341067839
10.10.2023
IN
202441054021
15.07.2024
IN
Application details
| Total Number of Claims/PCT | * |
| Number of Independent Claims | * |
| Number of Priorities | * |
| Number of Multi-Dependent Claims | * |
| Number of Drawings | * |
| Pages for Publication | * |
| Number of Pages with Drawings | * |
| Pages of Specification | * |
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| Number of Office Actions | * |
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International Searching Authority |
EPO
* |
| Recordal of a Change of the Applicant's Name/Address |
Change of Applicant's Name and Address
* |
| Type of Assignment |
The Standard Agent's Assignment
* |
| Applicant's Legal Status |
Legal Entity
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| * | |
| * | |
| * | |
| * | |
| * | |
| Entry into National Phase under |
Chapter I
* |
| Patent Delivery |
Send the Letters Patent by Courier
* |
| Translation |
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* The data is based on automatic recognition. Please verify and amend if necessary.
** IP-Coster compiles data from publicly available sources. If this data includes your personal information, you can contact us to request its removal.
Quotation for National Phase entry
| Country | Stages | Total | |
|---|---|---|---|
| China | Filing, Examination, Granting | 7040 | |
| EPO | Filing, Examination, Granting | 61957 | |
| Japan | Filing, Examination, Granting | 3882 | |
| South Korea | Filing, Examination, Granting | 5450 | |
| USA | Filing, Examination, Granting | 20440 |
Total:
98,769
The term for entry into the National Phase has expired. This quotation is for informational purposes only
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Abstract[English]
The present invention provides substituted tricyclic compound of formula (I), which are therapeutically useful as KRAS degraders. These compounds are useful in the treatment and/or prevention of diseases or disorders dependent upon KRAS. The present invention also provides pharmaceutical compositions comprising a compound of formula (I) or a pharmaceutically acceptable salt or a stereoisomer or a tautomer thereof thereof.[French]
La présente invention concerne des composés tricycliques substitués de formule (I), ayant une utilité thérapeutique en tant qu'agents de dégradation de KRAS. Ces composés sont utiles dans le traitement et/ou la prévention de maladies ou de troubles dépendant de KRAS. La présente invention concerne également des compositions pharmaceutiques comprenant un composé de formule (I) ou un sel pharmaceutiquement acceptable ou un stéréoisomère ou un tautomère de celui-ci.