WO2025052244 - PH-INDUCIBLE STRUCTURE-SWITCHING LIPID NANOVECTORS, SEMI-SYNTHETIC EXTRACELLULAR VESICLES, METHODS OF MAKING SAME AND USES THEREOF
National phase entry is expected:
Publication Number
WO/2025/052244
Publication Date
13.03.2025
International Application No.
PCT/IB2024/058555
International Filing Date
03.09.2024
Title **
[English]
PH-INDUCIBLE STRUCTURE-SWITCHING LIPID NANOVECTORS, SEMI-SYNTHETIC EXTRACELLULAR VESICLES, METHODS OF MAKING SAME AND USES THEREOF
[French]
NANOVECTEURS LIPIDIQUES À CHANGEMENT DE STRUCTURE INDUCTIBLES PAR PH, VÉSICULES EXTRACELLULAIRES SEMI-SYNTHÉTIQUES, LEURS PROCÉDÉS DE FABRICATION ET LEURS UTILISATIONS
Applicants **
ETH ZÜRICH
Inventors
LEROUX, Jean-Christophe
MONTANARI, Elita
BADER, Johannes
Priority Data
23195151.8
04.09.2023
EP
Application details
| Total Number of Claims/PCT | * |
| Number of Independent Claims | * |
| Number of Priorities | * |
| Number of Multi-Dependent Claims | * |
| Number of Drawings | * |
| Pages for Publication | * |
| Number of Pages with Drawings | * |
| Pages of Specification | * |
| * | |
| Number of Office Actions | * |
| * | |
International Searching Authority |
EPO
* |
| Recordal of a Change of the Applicant's Name/Address |
Change of Applicant's Name and Address
* |
| Type of Assignment |
The Standard Agent's Assignment
* |
| Applicant's Legal Status |
Legal Entity
* |
| * | |
| * | |
| * | |
| * | |
| * | |
| Entry into National Phase under |
Chapter I
* |
| Patent Delivery |
Send the Letters Patent by Courier
* |
| Translation |
|
* The data is based on automatic recognition. Please verify and amend if necessary.
** IP-Coster compiles data from publicly available sources. If this data includes your personal information, you can contact us to request its removal.
Quotation for National Phase entry
| Country | Stages | Total | |
|---|---|---|---|
| China | Filing, Examination, Granting | 2304 | |
| EPO | Filing, Examination, Granting | 9223 | |
| Japan | Filing, Examination, Granting | 2181 | |
| South Korea | Filing, Examination, Granting | 2043 | |
| USA | Filing, Examination, Granting | 8340 |
Total:
24,091
The term for entry into the National Phase has expired. This quotation is for informational purposes only
Contact Us
Abstract[English]
The present disclosure provides a pH-inducible structure-switching non-lamellar lipid nanovector (LNV) comprising: (a) at least one ionizable cationic lipid; (b) at least one phospholipid displaying a critical packing parameter (CPP) value > 1; and (c) at least one non-ionic surfactant displaying a CPP value < 1 at a molar concentration of between 20 % and 50 %, a method of making the LNV, a semi-synthetic extracellular vesicle (ssEV) resulting from the fusion of the LNV with extracellular vesicles at a pH higher than 6 and up to about 10, a kit and a use of the ssEV as a medicament or diagnostic agent.[French]
La présente divulgation concerne un nanovecteur lipidique (LNV) non lamellaire à changement de structure inductible par le pH comprenant : (a) au moins un lipide cationique ionisable; (b) au moins un phospholipide présentant une valeur de paramètre de remplissage critique (CPP) > 1; et (c) au moins un tensioactif non ionique présentant une valeur de CPP < 1 à une concentration molaire comprise entre 20% et 50%, un procédé de fabrication du LNV, une vésicule extracellulaire semi-synthétique (ssEV) résultant de la fusion du LNV avec des vésicules extracellulaires à un pH supérieur à 6 et allant jusqu'à environ 10, un kit et une utilisation du ssEV en tant que médicament ou agent de diagnostic.