WO2025041085 - DUAL NUCLEASE SYSTEMS FOR GENE EDITING, METHODS OF PRODUCING AND USING SAME
National phase entry is expected:
Publication Number
WO/2025/041085
Publication Date
27.02.2025
International Application No.
PCT/IB2024/058194
International Filing Date
22.08.2024
Title **
[English]
DUAL NUCLEASE SYSTEMS FOR GENE EDITING, METHODS OF PRODUCING AND USING SAME
[French]
SYSTÈMES À DOUBLE NUCLÉASE POUR ÉDITION DE GÈNES, LEURS PROCÉDÉS DE PRODUCTION ET D'UTILISATION
Applicants **
SPECIFIC BIOLOGICS INC.
Inventors
HUYNH, Nhan
STEAD, Brent
Priority Data
63/578,032
22.08.2023
US
63/590,771
16.10.2023
US
63/631,166
08.04.2024
US
Application details
| Total Number of Claims/PCT | * |
| Number of Independent Claims | * |
| Number of Priorities | * |
| Number of Multi-Dependent Claims | * |
| Number of Drawings | * |
| Pages for Publication | * |
| Number of Pages with Drawings | * |
| Pages of Specification | * |
| * | |
| Number of Office Actions | * |
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International Searching Authority |
CIPO
* |
| Recordal of a Change of the Applicant's Name/Address |
Change of Applicant's Name and Address
* |
| Type of Assignment |
The Standard Agent's Assignment
* |
| Applicant's Legal Status |
Legal Entity
* |
| * | |
| * | |
| * | |
| * | |
| * | |
| Entry into National Phase under |
Chapter I
* |
| Patent Delivery |
Send the Letters Patent by Courier
* |
| Translation |
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* The data is based on automatic recognition. Please verify and amend if necessary.
** IP-Coster compiles data from publicly available sources. If this data includes your personal information, you can contact us to request its removal.
Quotation for National Phase entry
| Country | Stages | Total | |
|---|---|---|---|
| China | Filing, Examination, Granting | 8077 | |
| EPO | Filing, Examination, Granting | 94246 | |
| Japan | Filing, Examination, Granting | 4571 | |
| South Korea | Filing, Examination, Granting | 7206 | |
| USA | Filing, Examination, Granting | 32490 |
Total:
146,590
The term for entry into the National Phase has expired. This quotation is for informational purposes only
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Abstract[English]
Provided herein are dual cleaving chimeric nucleases comprising an I-TevI domain and a RNA-guided domain such as Cas9 for use in gene editing methods, as well as chimeric nuclease systems comprising a single nucleic acid that encodes said chimeric nuclease, one or more guide RNAs (gRNAs), one or more tRNAs, and optionally one or more donor polynucleotides. Also provided herein are methods of making and using such chimeric nucleases, chimeric nuclease systems, and nucleic acids encoding such chimeric nucleases and chimeric nuclease systems.[French]
L'invention concerne des nucléases chimériques à double clivage comprenant un domaine I-TevI et un domaine guidé par ARN tel que Cas9 destiné à être utilisé dans des procédés d'édition génique, ainsi que des systèmes de nucléase chimériques comprenant un acide nucléique unique qui code ladite nucléase chimérique, un ou plusieurs ARN guides (ARNg), un ou plusieurs ARNt et éventuellement un ou plusieurs polynucléotides donneurs. L'invention concerne également des procédés de fabrication et d'utilisation de telles nucléases chimériques, des systèmes de nucléase chimériques et des acides nucléiques codant pour de telles nucléases chimériques et de tels systèmes de nucléase chimériques.