WO2025032465 - USE OF GARDOS CHANNEL INHIBITORS IN THE TREATMENT OF SICKLE CELL DISEASE
National phase entry:
Publication Number
WO/2025/032465
Publication Date
13.02.2025
International Application No.
PCT/IB2024/057522
International Filing Date
02.08.2024
Title **
[English]
USE OF GARDOS CHANNEL INHIBITORS IN THE TREATMENT OF SICKLE CELL DISEASE
[French]
UTILISATION D'INHIBITEURS DU CANAL GARDOS DANS LE TRAITEMENT DE LA DRÉPANOCYTOSE
Applicants **
BIOSSIL INC.
Inventors
MOSA, Alexander Ibrahim
MOUCHANTAF, Anthony
Priority Data
63/530,887
04.08.2023
US
63/627,319
31.01.2024
US
Application details
| Total Number of Claims/PCT | * |
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International Searching Authority |
CIPO
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| Recordal of a Change of the Applicant's Name/Address |
Change of Applicant's Name and Address
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| Type of Assignment |
The Standard Agent's Assignment
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| Applicant's Legal Status |
Legal Entity
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| Entry into National Phase under |
Chapter I
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| Patent Delivery |
Send the Letters Patent by Courier
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| Translation |
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Quotation for National Phase entry
| Country | Stages | Total | |
|---|---|---|---|
| China | Filing, Examination, Granting | 2445 | |
| EPO | Filing, Examination, Granting | 15877 | |
| Japan | Filing, Examination, Granting | 2431 | |
| South Korea | Filing, Examination, Granting | 2658 | |
| USA | Filing, Examination, Granting | 5940 |
Total:
29,351
The term for entry into the National Phase has expired. This quotation is for informational purposes only
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Abstract[English]
Provided herein are methods of treating sickle cell disease, methods of increasing hemoglobin levels in a subject diagnosed with sickle cell disease, and methods of reducing hemolysis-associated complications in a subject diagnosed with sickle cell disease, in a subject in need thereof, comprising administering a Gardos channel inhibitor such as 2,2- bis(4-fluorophenyl)-2-phenylacetamide to the subject. Subjects eligible for treatment include subjects as having hemolysis dominant (HD) sickle cell disease on the basis of laboratory markers, clinical history, and/or sequelae.[French]
L'invention concerne des méthodes de traitement de la drépanocytose, des méthodes d'augmentation des taux d'hémoglobine chez un sujet chez qui on a diagnostiqué la drépanocytose, et des méthodes de réduction des complications associées à l'hémolyse chez un sujet chez qui on a diagnostiqué la drépanocytose, chez un sujet en ayant besoin, comprenant l'administration au sujet d'un inhibiteur du canal Gardos tel que le 2,2-bis(4-fluorophényl)-2-phénylacétamide. Les sujets éligibles au traitement comprennent des sujets ayant une drépanocytose à dominance hémolytique (HD) sur la base de marqueurs de laboratoire, de l'historique clinique et/ou des séquelles.