WO2025027521 - AN IMPROVED PROCESS FOR THE PREPARATION OF AVIBACTAM AND INTERMEDIATE THEREOF
National phase entry:
Publication Number
WO/2025/027521
Publication Date
06.02.2025
International Application No.
PCT/IB2024/057358
International Filing Date
30.07.2024
Title **
[English]
AN IMPROVED PROCESS FOR THE PREPARATION OF AVIBACTAM AND INTERMEDIATE THEREOF
[French]
PROCÉDÉ AMÉLIORÉ POUR LA PRÉPARATION D'AVIBACTAM ET DE SES INTERMÉDIAIRES
Applicants **
FRESENIUS KABI ONCOLOGY LTD.
Inventors
DHAVARIA, Sandeep
HANDA, Vishal
SHARMA, Suneel Kumar
MEHTA, Anshu Kumar
SINGH, Aditya Narayan
ABUL, Azim
GUPTA, Nitin
SINGH, Govind
CABRI, Walter
Priority Data
202311051633
01.08.2023
IN
Application details
| Total Number of Claims/PCT | * |
| Number of Independent Claims | * |
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| Number of Multi-Dependent Claims | * |
| Number of Drawings | * |
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International Searching Authority |
EPO
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| Recordal of a Change of the Applicant's Name/Address |
Change of Applicant's Name and Address
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| Type of Assignment |
The Standard Agent's Assignment
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| Applicant's Legal Status |
Legal Entity
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| Entry into National Phase under |
Chapter I
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| Patent Delivery |
Send the Letters Patent by Courier
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| Translation |
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* The data is based on automatic recognition. Please verify and amend if necessary.
** IP-Coster compiles data from publicly available sources. If this data includes your personal information, you can contact us to request its removal.
Quotation for National Phase entry
| Country | Stages | Total | |
|---|---|---|---|
| China | Filing, Examination, Granting | 2521 | |
| EPO | Filing, Examination, Granting | 15262 | |
| Japan | Filing, Examination, Granting | 2573 | |
| South Korea | Filing, Examination, Granting | 2853 | |
| USA | Filing, Examination, Granting | 7540 |
Total:
30,749
The term for entry into the National Phase has expired. This quotation is for informational purposes only
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Abstract[English]
is a hydroxy protecting group which is a key intermediate for Avibactam or a pharmaceutically acceptable salt thereof. The present invention also relates to the crystalline form of intermediates used for the synthesis of Avibactam or a pharmaceutically acceptable salt thereof. The invention also provides improved processes for the preparation of Avibactam or a pharmaceutically acceptable salt, using the bridged ester compound of formula I prepared by the process of the present invention.[French]
étant un groupe protecteur d'hydroxy qui est un intermédiaire clé pour l'avibactam ou un sel pharmaceutiquement acceptable de celui-ci. La présente invention concerne également une forme cristalline d'intermédiaires utilisés pour la synthèse d'avibactam ou d'un sel pharmaceutiquement acceptable de celui-ci. L'invention concerne en outre des procédés améliorés pour la préparation d'avibactam ou d'un sel pharmaceutiquement acceptable, à l'aide du composé ester ponté de formule I préparé par le procédé selon la présente invention.