WO2025027498 - MULTIDOSE PRESERVATIVE-FREE (MDPF) OPHTHALMIC DOSE DELIVERY WITH ADDITION OF FORMULATION SURFACTANTS

National phase entry:
Publication Number WO/2025/027498
Publication Date 06.02.2025
International Application No. PCT/IB2024/057314
International Filing Date 29.07.2024
Title **
[English] MULTIDOSE PRESERVATIVE-FREE (MDPF) OPHTHALMIC DOSE DELIVERY WITH ADDITION OF FORMULATION SURFACTANTS
[French] ADMINISTRATION DE DOSE OPHTALMIQUE SANS CONSERVATEUR MULTIDOSE (MDPF) AVEC AJOUT DE TENSIOACTIFS DE FORMULATION
Applicants **
ALCON INC.
Inventors
LIAO, Hongzhu
KOLEGA, Randall Renato
Priority Data
63/517,360   03.08.2023   US
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Quotation for National Phase entry

Country StagesTotal
China Filing, Examination, Granting2274
EPO Filing, Examination, Granting10434
Japan Filing, Examination, Granting2294
South Korea Filing, Examination, Granting2216
USA Filing, Examination, Granting8340
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Total: 25,558

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Abstract[English] The present disclosure generally relates to ophthalmic compositions and multidose systems for topically applying compositions to a surface, e.g. an eye surface. Multidose systems of the present disclosure can include a multidose preservative-free (MDPF) eye dropper bottle system and an ophthalmic composition having an therapeutic agent, a viscosifying agent having a concentration of about 0.01 %w/v to about 5 %w/v, and a surfactant having a concentration of about 0.005 %w/v to about 7 %w/, wherein the composition lacks a preservative.[French] La présente invention concerne de manière générale des compositions ophtalmiques et des systèmes multidoses pour l'application topique de compositions sur une surface, par exemple une surface oculaire. Les systèmes multidoses de la présente invention peuvent comprendre un système de bouteille compte-gouttes oculaires sans conservateur multidose (MDPF) et une composition ophtalmique ayant un agent thérapeutique, un agent viscosifiant ayant une concentration d'environ 0,01 % p/v à environ 5 % p/v, et un tensioactif ayant une concentration d'environ 0,005 % p/v à environ 7 % p/v, la composition étant dépourvue d'un conservateur.

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