WO2024214078 - CARBOXAMIDE COMPOUNDS AS SUMO ACTIVATING AND E1 LIGASE ACTIVATING COMPOUNDS FOR USE IN TREATING CARDIOVASCULAR DISEASES
National phase entry:
Publication Number
WO/2024/214078
Publication Date
17.10.2024
International Application No.
PCT/IB2024/053629
International Filing Date
12.04.2024
Title **
[English]
CARBOXAMIDE COMPOUNDS AS SUMO ACTIVATING AND E1 LIGASE ACTIVATING COMPOUNDS FOR USE IN TREATING CARDIOVASCULAR DISEASES
[French]
COMPOSÉS DE CARBOXAMIDE EN TANT QUE COMPOSÉS D'ACTIVATION DE SUMO ET D'ACTIVATION DE LIGASE E1 DESTINÉS À ÊTRE UTILISÉS DANS LE TRAITEMENT DE MALADIES CARDIOVASCULAIRES
Applicants **
NOVOHEART INTERNATIONAL LIMITED
Inventors
WONG, Andy
LI, Ronald
HAJJAR, Roger
Priority Data
63/459,063
13.04.2023
US
Application details
| Total Number of Claims/PCT | * |
| Number of Independent Claims | * |
| Number of Priorities | * |
| Number of Multi-Dependent Claims | * |
| Number of Drawings | * |
| Pages for Publication | * |
| Number of Pages with Drawings | * |
| Pages of Specification | * |
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| Number of Office Actions | * |
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International Searching Authority |
EPO
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| Recordal of a Change of the Applicant's Name/Address |
Change of Applicant's Name and Address
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| Type of Assignment |
The Standard Agent's Assignment
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| Applicant's Legal Status |
Legal Entity
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| * | |
| * | |
| * | |
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| Entry into National Phase under |
Chapter I
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| Patent Delivery |
Send the Letters Patent by Courier
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| Translation |
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* The data is based on automatic recognition. Please verify and amend if necessary.
** IP-Coster compiles data from publicly available sources. If this data includes your personal information, you can contact us to request its removal.
Quotation for National Phase entry
| Country | Stages | Total | |
|---|---|---|---|
| China | Filing, Examination, Granting | 3040 | |
| EPO | Filing, Examination, Granting | 22477 | |
| Japan | Filing, Examination, Granting | 2993 | |
| South Korea | Filing, Examination, Granting | 3638 | |
| USA | Filing, Examination, Granting | 10740 |
Total:
42,888
The term for entry into the National Phase has expired. This quotation is for informational purposes only
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Abstract[English]
Disclosed are carboxamide derivative compounds effective as therapeutics in treating heart disease such as heart failure, cardiomyopathy, diastolic dysfunction, and the heart disease aspect of other diseases or disorders, such as muscular dystrophy. Also disclosed are methods of treating subjects with such diseases and methods of screening for compounds effective as therapeutic in treating such diseases. The screening methods provide rapid ex vivo approaches to identifying therapeutics that involve the use of cardiac tissue strips, polymeric substrates such as polydimethylsiloxane that have posts with curved features to retain tissues and measure contractile force of cardiomyocyte tissue strips, and/or one or more cardiac organoids in chambered devices to facilitate manipulation and monitoring.[French]
Sont divulgués des composés dérivés de carboxamide efficaces en tant qu'agents thérapeutiques dans le traitement d'une maladie cardiaque telle qu'une insuffisance cardiaque, une cardiomyopathie, un dysfonctionnement diastolique, et l'aspect de maladie cardiaque d'autres maladies ou troubles, tels que la dystrophie musculaire. Sont divulguées également des méthodes de traitement de sujets atteints de ces maladies et des méthodes de criblage de composés efficaces en tant qu'agents thérapeutiques dans le traitement de ces maladies. Les méthodes de criblage fournissent des approches ex vivo rapides pour identifier des agents thérapeutiques qui impliquent l'utilisation de bandes de tissu cardiaque, de substrats polymères tels que le polydiméthylsiloxane qui ont des piliers ayant des caractéristiques incurvées pour retenir des tissus et mesurer une force contractile de bandes de tissu de cardiomyocytes, et/ou d'un ou de plusieurs organoïdes cardiaques dans des dispositifs à chambre pour faciliter la manipulation et la surveillance.