WO2025120370 - COMPOSITIONS AND METHODS FOR SOLUTION-PHASE, PHOSPHORAMIDITE-FREE SYNTHESIS OF NUCLEIC ACIDS
National phase entry is expected:
Publication Number
WO/2025/120370
Publication Date
12.06.2025
International Application No.
PCT/IB2024/000703
International Filing Date
06.12.2024
Title **
[English]
COMPOSITIONS AND METHODS FOR SOLUTION-PHASE, PHOSPHORAMIDITE-FREE SYNTHESIS OF NUCLEIC ACIDS
[French]
COMPOSITIONS ET PROCÉDÉS DE SYNTHÈSE D'ACIDES NUCLÉIQUES SANS PHOSPHORAMIDITE EN PHASE SOLUBLE
Applicants **
CAMENA BIOSCIENCE LIMITED
Inventors
ARNOLD, Corinne
STEMPLE, Derek, L.
CHRISTIE, Gabrielle
ALLEN, James
RICHARDSON, James
PRIMO, Maria
HOLBROOK, Nadin
Priority Data
63/608,002
08.12.2023
US
Application details
| Total Number of Claims/PCT | * |
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| Number of Multi-Dependent Claims | * |
| Number of Drawings | * |
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International Searching Authority |
EPO
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| Recordal of a Change of the Applicant's Name/Address |
Change of Applicant's Name and Address
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| Type of Assignment |
The Standard Agent's Assignment
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| Applicant's Legal Status |
Legal Entity
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| Entry into National Phase under |
Chapter I
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| Patent Delivery |
Send the Letters Patent by Courier
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| Translation |
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* The data is based on automatic recognition. Please verify and amend if necessary.
** IP-Coster compiles data from publicly available sources. If this data includes your personal information, you can contact us to request its removal.
Quotation for National Phase entry
| Country | Stages | Total | |
|---|---|---|---|
| China | Filing, Examination, Granting | 3922 | |
| EPO | Filing, Examination, Granting | 49953 | |
| Japan | Filing, Examination, Granting | 3838 | |
| South Korea | Filing, Examination, Granting | 5193 | |
| USA | Filing, Examination, Granting | 14740 |
Total:
77,646
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Abstract[English]
Disclosed herein are the compositions and methods for solution-phase, phosphoramidite-free synthesis of nucleic acids, known as addamers. The addamers may be synthesized for any arbitrary sequence of DNA at any arbitrary length with a 3' base pair overhang in solution. Accordingly, disclosed herein are addamer reagents generated from bacterial plasmids as well as bacterially expressed, purified enzymes used to generate any given Nucleic Acid (NA) sequence in a process referred to as GreenSynth.[French]
L'invention divulgue des compositions et des procédés de synthèse d'acides nucléiques sans phosphoramidite en phase soluble, appelés addamers. Les addamers peuvent être synthétisés pour n'importe quelle séquence arbitraire d'ADN, quelle que soit la longueur, avec un surplan de paire de bases en position 3' en solution. Par conséquent, l'invention divulgue des réactifs addamers générés à partir de plasmides bactériens ainsi que des enzymes purifiées exprimées de manière bactérienne utilisées pour générer n'importe quelle séquence d'acide nucléique (NA) donnée dans un processus appelé GreenSynth.