WO2024127333 - CYTOTOXIC COMPOUNDS

National phase entry is expected:
Publication Number WO/2024/127333
Publication Date 20.06.2024
International Application No. PCT/IB2023/062734
International Filing Date 14.12.2023
Title **
[English] CYTOTOXIC COMPOUNDS
[French] COMPOSÉS CYTOTOXIQUES
Applicants **
PHEON THERAPEUTICS LTD
Inventors
ANDRIOLLO, Paolo
PROCOPIOU, George
JACKSON, Paul
Priority Data
63/387,436   14.12.2022   US
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Quotation for National Phase entry

Country StagesTotal
China Filing, Examination, Granting3612
EPO Filing, Examination, Granting23871
Japan Filing, Examination, Granting2917
South Korea Filing, Examination, Granting3516
USA Filing, Examination, Granting10640
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Total: 44,556

The term for entry into the National Phase has expired. This quotation is for informational purposes only

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Abstract[English] The present disclosure provides compounds having a 6-7-5 membered ring or 6-7-6 membered ring comprising a 1,4-benzodiazepine ring comprising an A ring and an imine nitrogen, wherein a hydrogen bond donor, a hydrogen bond acceptor, an electron withdrawing group, or an electron donating group is present on the A ring at a position para to the imine nitrogen, and conjugates thereof useful for treating cancer.[French] La présente invention concerne des composés ayant un cycle à 6-7-5 chaînons ou un cycle à 6-7-6 chaînons comprenant un cycle 1,4-benzodiazépine comprenant un cycle et un azote imine, un donneur de liaison hydrogène, un accepteur de liaison hydrogène, un groupe attracteur d'électrons, ou un groupe donneur d'électrons étant présent sur le cycle à une position para par rapport à l'azote imine, et des conjugués de ceux-ci utiles pour le traitement du cancer.

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