WO2025052163 - 2-AMINO-N-(BENZO[D]THIAZOL-2-YLSULFONYL)-3-HYDROXYBUTANAMIDE DERIVATIVES ACTING AS A THREONYL-T-RNA SYNTHETASE INHBITORS FOR THE TREATMENT OF MALARIA
National phase entry is expected:
Publication Number
WO/2025/052163
Publication Date
13.03.2025
International Application No.
PCT/IB2023/058844
International Filing Date
07.09.2023
Title **
[English]
2-AMINO-N-(BENZO[D]THIAZOL-2-YLSULFONYL)-3-HYDROXYBUTANAMIDE DERIVATIVES ACTING AS A THREONYL-T-RNA SYNTHETASE INHBITORS FOR THE TREATMENT OF MALARIA
[French]
DÉRIVÉS DE 2-AMINO-N-(BENZO[D]THIAZOL-2-YLSULFONYL)-3-HYDROXYBUTANAMIDE AGISSANT EN TANT QU'INHIBITEURS DE THRÉONYL-T-ARN SYNTHÉTASE POUR LE TRAITEMENT DU PALUDISME
Applicants **
LATVIAN INSTITUTE OF ORGANIC SYNTHESIS
Inventors
JIRGENSONS, Aigars
BOLSAKOVA, Jekaterina
BOBROVS, Raitis
VARACEVA, Larisa
Application details
| Total Number of Claims/PCT | * |
| Number of Independent Claims | * |
| Number of Priorities | * |
| Number of Multi-Dependent Claims | * |
| Number of Drawings | * |
| Pages for Publication | * |
| Number of Pages with Drawings | * |
| Pages of Specification | * |
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| Number of Office Actions | * |
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International Searching Authority |
EPO
* |
| Recordal of a Change of the Applicant's Name/Address |
Change of Applicant's Name and Address
* |
| Type of Assignment |
The Standard Agent's Assignment
* |
| Applicant's Legal Status |
Legal Entity
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| * | |
| * | |
| * | |
| * | |
| * | |
| Entry into National Phase under |
Chapter I
* |
| Patent Delivery |
Send the Letters Patent by Courier
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| Translation |
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* The data is based on automatic recognition. Please verify and amend if necessary.
** IP-Coster compiles data from publicly available sources. If this data includes your personal information, you can contact us to request its removal.
Quotation for National Phase entry
| Country | Stages | Total | |
|---|---|---|---|
| China | Filing, Examination, Granting | 1806 | |
| EPO | Filing, Examination, Granting | 8141 | |
| Japan | Filing, Examination, Granting | 1890 | |
| South Korea | Filing, Examination, Granting | 1407 | |
| USA | Filing, Examination, Granting | 4740 |
Total:
17,984
The term for entry into the National Phase has expired. This quotation is for informational purposes only
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Abstract[English]
Representatives of 2-amino-N-(benzo[d]thiazol-2-ylsulfonyl)-3-hydroxybutanamide with general formula (I) show potency to inhibit malarial threonyl-tRNA synthetase (ThrRS) in low micromolar to nanomolar concentrations. As such they can be applied as compounds for prevention or treatment of malaria.[French]
Des représentants de 2-amino-N-(benzo[d]thiazol-2-ylsulfonyl)-3-hydroxybutanamide de formule générale (I) présentent une puissance pour inhiber la thréonyl-ARNt synthétase (ThrRS) paludique en faibles concentrations micromolaires à nanomolaires. Ainsi, ils peuvent être appliqués en tant que composés pour la prévention ou le traitement du paludisme.