WO2024018363 - ADENO-ASSOCIATED VIRUS VECTORS EMPTY/FULL RATIO ANALYSIS USING CE- BASED GENOME AND CAPSID QUANTIFICATION

National phase entry:
Publication Number WO/2024/018363
Publication Date 25.01.2024
International Application No. PCT/IB2023/057276
International Filing Date 17.07.2023
Title **
[English] ADENO-ASSOCIATED VIRUS VECTORS EMPTY/FULL RATIO ANALYSIS USING CE- BASED GENOME AND CAPSID QUANTIFICATION
[French] ANALYSE DE RAPPORT VIDE/PLEIN DE VECTEURS DE VIRUS ADÉNO-ASSOCIÉS À L'AIDE D'UN GÉNOME BASÉ SUR CE ET D'UNE QUANTIFICATION DE CAPSIDES
Applicants **
DH TECHNOLOGIES DEVELOPMENT PTE. LTD.
Inventors
JONES, Elliott
LI, Tingting
LUO, Jane
MOLLAH, Sahana
Priority Data
63/390,414   19.07.2022   US
63/453,813   22.03.2023   US
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Quotation for National Phase entry

Country StagesTotal
China Filing, Examination, Granting4033
EPO Filing, Examination, Granting62423
Japan Filing, Examination, Granting4138
South Korea Filing, Examination, Granting5977
USA Filing, Examination, Granting16340
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Total: 92,911

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Abstract[English] The presently described and claimed disclosure relates to capillary electrophoresis methods for quantifying an intact AAV genome and protein components in an AAV using the same capillary electrophoresis system. The claimed and described approach offers an automated analysis of AAV samples and provides information to determine the AAV empty/full ratio.[French] La présente invention concerne des procédés d'électrophorèse capillaire pour quantifier un génome d'AAV intact et des composants de protéine dans un AAV à l'aide du même système d'électrophorèse capillaire. L'approche revendiquée et décrite offre une analyse automatisée d'échantillons d'AAV et fournit des informations pour déterminer le rapport vide/plein d'AAV.

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