WO2024009184 - DISSOCIATION METHOD AND SYSTEM OF DEPROTONATED PEPTIDES WITH FRAGILE MOIETIES
National phase entry:
Publication Number
WO/2024/009184
Publication Date
11.01.2024
International Application No.
PCT/IB2023/056799
International Filing Date
29.06.2023
Title **
[English]
DISSOCIATION METHOD AND SYSTEM OF DEPROTONATED PEPTIDES WITH FRAGILE MOIETIES
[French]
PROCÉDÉ ET SYSTÈME DE DISSOCIATION DE PEPTIDES DÉPROTONÉS AVEC FRACTIONS FRAGILES
Applicants **
DH TECHNOLOGIES DEVELOPMENT PTE. LTD.
Inventors
BABA, Takashi
LIU, Haichuan
ZHANG, Yuzhuo
Priority Data
63/358,752
06.07.2022
US
Application details
| Total Number of Claims/PCT | * |
| Number of Independent Claims | * |
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| Number of Multi-Dependent Claims | * |
| Number of Drawings | * |
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International Searching Authority |
EPO
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| Recordal of a Change of the Applicant's Name/Address |
Change of Applicant's Name and Address
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| Type of Assignment |
The Standard Agent's Assignment
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| Applicant's Legal Status |
Legal Entity
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| Entry into National Phase under |
Chapter I
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| Patent Delivery |
Send the Letters Patent by Courier
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| Translation |
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Quotation for National Phase entry
| Country | Stages | Total | |
|---|---|---|---|
| China | Filing, Examination, Granting | 2168 | |
| EPO | Filing, Examination, Granting | 10701 | |
| Japan | Filing, Examination, Granting | 2325 | |
| South Korea | Filing, Examination, Granting | 2371 | |
| USA | Filing, Examination, Granting | 4740 |
Total:
22,305
The term for entry into the National Phase has expired. This quotation is for informational purposes only
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Abstract[English]
A method for mass spectrometric analysis of a peptide having at least one fragile moiety includes using electrospray ionization to generate a negatively charged ion of said peptide, trapping and cooling the negatively charged peptide ion in a radiofrequency (RF) ion trap containing a cooling buffer gas, and exposing said cooled, trapped peptide ion to an electron beam so as to cause negative electron activated dissociation (negative EAD) of the negatively charged peptide ion to generate a plurality of fragment ions.[French]
L'invention concerne un procédé d’analyse par spectrométrie de masse d’un peptide possédant au moins une fraction fragile, qui comprend les étapes consistant à utiliser une ionisation par électronébulisation pour générer un ion chargé négativement dudit peptide, à piéger et à refroidir l’ion de peptide chargé négativement dans un piège à ions à radiofréquence (RF) contenant un gaz tampon de refroidissement, et à exposer ledit ion de peptide piégé refroidi à un faisceau d’électrons de façon à provoquer une dissociation négative induite par électrons (EAD négative) de l’ion de peptide chargé négativement pour générer une pluralité d’ions fragmentaires.