WO2023238101 - METHODS FOR PRODUCING GAMMA-CYCLODEXTRINS

National phase entry:
Publication Number WO/2023/238101
Publication Date 14.12.2023
International Application No. PCT/IB2023/055979
International Filing Date 09.06.2023
Title **
[English] METHODS FOR PRODUCING GAMMA-CYCLODEXTRINS
[French] PROCÉDÉS DE PRODUCTION DE GAMMA-CYCLODEXTRINES
Applicants **
BEREN THERAPEUTICS P.B.C
Inventors
GROBAN, Eli
HU, Karl
PFEIFFER, Steven
RIZKIN, Benjamin
BENKOVICS, Gabor
Priority Data
PCT/CN2022/098239   10.06.2022   CN
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Quotation for National Phase entry

Country StagesTotal
China Filing, Examination, Granting3034
EPO Filing, Examination, Granting21934
Japan Filing, Examination, Granting2962
South Korea Filing, Examination, Granting3576
USA Filing, Examination, Granting9340
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Total: 40,846

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Abstract[English] Provided herein are methods for the enzymatic production of gamma-cyclodextrin from sucrose. In some cases, the methods involve contacting sucrose with one or more enzymes to convert sucrose to amylose, followed by contacting the amylose with one or more enzymes to convert the amylose to gamma-cyclodextrin. In some cases, the methods produce higher yields of gamma-cyclodextrin relative to alpha-cyclodextrin, beta-cyclodextrin, or both.[French] L'invention concerne des procédés de production enzymatique de gamma-cyclodextrine à partir de saccharose. Dans certains cas, les procédés consistent à mettre en contact du saccharose avec une ou plusieurs enzymes pour convertir le saccharose en amylose, puis à mettre en contact l'amylose avec une ou plusieurs enzymes pour convertir l'amylose en gamma-cyclodextrine. Dans certains cas, les procédés produisent des rendements plus élevés de gamma-cyclodextrine par rapport à l'α-cyclodextrine, à la bêta-cyclodextrine, ou aux deux.

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