WO2023238078 - )-ENGINEERED OXYNITRILASE POLYPEPTIDES AND USES THEREOF
National phase entry:
Publication Number
WO/2023/238078
Publication Date
14.12.2023
International Application No.
PCT/IB2023/055923
International Filing Date
08.06.2023
Title **
[English]
)-ENGINEERED OXYNITRILASE POLYPEPTIDES AND USES THEREOF
[French]
) ET LEURS UTILISATIONS
Applicants **
NOVARTIS AG
Inventors
ALVIZO, Oscar
LUESCHER, Michael Umberto
MANN, Gregory
MARTIN, Benjamin
NOVICK, Scott J.
Ó MEADHRA, Ruairí Seosamh
PESCHKE, Theo
SCHLAMA, Thierry
SCHOBER, Lukas Christian
SCHROER, Kirsten
STANGER, Frederic
SUBRAMANIAN, Nandhitha
TRUNG, Nhat Quang Nguyen
Priority Data
63/350,047
08.06.2022
US
Application details
| Total Number of Claims/PCT | * |
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| Number of Drawings | * |
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International Searching Authority |
EPO
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| Recordal of a Change of the Applicant's Name/Address |
Change of Applicant's Name and Address
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| Type of Assignment |
The Standard Agent's Assignment
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| Applicant's Legal Status |
Legal Entity
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| Entry into National Phase under |
Chapter I
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| Patent Delivery |
Send the Letters Patent by Courier
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| Translation |
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Quotation for National Phase entry
| Country | Stages | Total | |
|---|---|---|---|
| China | Filing, Examination, Granting | 4029 | |
| EPO | Filing, Examination, Granting | 48536 | |
| Japan | Filing, Examination, Granting | 3774 | |
| South Korea | Filing, Examination, Granting | 5171 | |
| USA | Filing, Examination, Granting | 18590 |
Total:
80,100
The term for entry into the National Phase has expired. This quotation is for informational purposes only
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Abstract[English]
The present disclosure relates to a process for producing chiral β-nitro alcohol compounds. The invention relates in particular to an (S)-selective oxynitrilase, which enantioselectively can catalyze the Henry reaction, wherein an aldehyde or ketone compound is converted to the corresponding β-nitro alcohol compound in the presence of a nitroalkane compound and an oxynitrilase.[French]
La présente divulgation concerne un procédé de production de composés de β-nitro-alcools chiraux. La présente divulgation concerne plus particulièrement une oxynitrilase (S)-sélective, qui peut catalyser de manière énantiosélective la réaction de Henry, dans laquelle un composé aldéhyde ou cétone est converti en composé β-nitro-alcool correspondant en présence d'un composé nitro-alcane et d'une oxynitrilase.